David E Clemmer

US Patent:

6498342, Dec 24, 2002

Filed:

Jul 13, 2000

Appl. No.:

09/615102

Inventors:

David E. Clemmer - Gosport IN

Assignee:

Advanced Research Technology Institute - Indianapolis IN

International Classification:

H01J 4940

US Classification:

250287

Abstract:

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. In one embodiment, the ion source includes a molecule separation instrument operable to separate ions in time according to a molecular characteristic such as ion retention time. The resultant instrument is thus operable to provide molecular information separated in time as functions of retention time, ion mobility and ion mass/charge. In another embodiment, the ion separation instrument includes first and second ion mobility instruments disposed in a cascade arrangement between the ion source and mass spectrometer, wherein the two ion mobility instruments are operable to separate ions in time each according to different ion mobility functions. For example, the two ion mobility instruments may have different flight tube lengths, operate at different temperatures, operate in the presence of different electric fields and/or operate in the presence of different gases. The resultant instrument is thus operable to provide molecular information separated in time according to at least two different functions of ion mobility as well as ion mass/charge.

US Patent:

6559441, May 6, 2003

Filed:

Feb 12, 2002

Appl. No.:

10/074210

Inventors:

David E. Clemmer - Gosport IN

Assignee:

Advanced Research Technology Institute - Indianapolis IN

International Classification:

H01J 4940

US Classification:

250287, 73 1902, 73 6152

Abstract:

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. In one embodiment, the ion source includes a molecule separation instrument operable to separate ions in time according to a molecular characteristic such as ion retention time. The resultant instrument is thus operable to provide molecular information separated in time as functions of retention time, ion mobility and ion mass/charge. In another embodiment, the ion separation instrument includes first and second ion mobility instruments disposed in a cascade arrangement between the ion source and mass spectrometer, wherein the two ion mobility instruments are operable to separate ions in time each according to different ion mobility functions. For example, the two ion mobility instruments may have different flight tube lengths, operate at different temperatures, operate in the presence of different electric fields and/or operate in the presence of different gases. The resultant instrument is thus operable to provide molecular information separated in time according to at least two different functions of ion mobility as well as ion mass/charge.

US Patent:

6960761, Nov 1, 2005

Filed:

Apr 25, 2001

Appl. No.:

09/842383

Inventors:

David E. Clemmer - Gosport IN, US

Assignee:

Advanced Research & Technology Institute - Indianapolis IN

International Classification:

B01D059/44
B01J049/00

US Classification:

250287

Abstract:

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.

US Patent:

7077944, Jul 18, 2006

Filed:

Nov 10, 2003

Appl. No.:

10/704742

Inventors:

David E. Clemmer - Gosport IN, US

Assignee:

Indiana University Research and Technology Corporation - Indianapolis IN

International Classification:

H01J 49/40

US Classification:

205287, 205282

Abstract:

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and/or mass reaction instrumentation.

US Patent:

7838821, Nov 23, 2010

Filed:

Jan 21, 2009

Appl. No.:

12/357198

Inventors:

David E. Clemmer - Bloomington IN, US
Ruwan T. Kurulugama - Richland WA, US
Fabiane M. Nachtigall - Bloomington IN, US
Zachary Henson - Bloomington IN, US
Samuel I. Merenbloom - Bloomington IN, US
Stephen J. Valentine - Bloomington IN, US

Assignee:

Indiana University Research and Technology Corporation - Indianapolis IN

International Classification:

H01J 49/00
B01D 59/44

US Classification:

250281, 250282, 250288, 250287

Abstract:

An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that applies switched electric fields at a specified switching rate to the drift tube segments to thereby produce at the ion outlet only ions having a predefined ion mobility or range of ion mobilities.

US Patent:

8362420, Jan 29, 2013

Filed:

Aug 31, 2007

Appl. No.:

12/439108

Inventors:

David E. Clemmer - Bloomington IN, US
Samuel I. Merenbloom - El Cerrito CA, US
Stormy L. Koeniger - Evanston IL, US
Stephen J. Valentine - Bloomington IN, US

Assignee:

Indiana University Research and Technology Corporation - Indianapolis IN

International Classification:

B01D 59/44

US Classification:

250287, 250281, 250282, 250283, 250286, 250288, 250289

Abstract:

An apparatus () for separating Ions based on ion mobility includes a conduit () defining a closed path. The conduit is configured such that a uniform electric field is produced about the closed path upon application of a voltage causing ions within the conduit () to move about the closed path and to separate the ions based upon ion mobility. A method of separating a plurality of ions is also disclosed.

US Patent:

8513591, Aug 20, 2013

Filed:

Nov 22, 2010

Appl. No.:

12/952109

Inventors:

David E. Clemmer - Bloomington IN, US
Ruwan T. Kurulugama - Richland WA, US
Fabiane M. Nachtigall - Machado, BR
Zachary Henson - Santa Barbara CA, US
Samuel I. Merenbloom - Richmond CA, US
Stephen J. Valentine - Bloomington IN, US

Assignee:

Indiana University Reseach and Technology Corporation - Indianapolis IN

International Classification:

H01J 49/42

US Classification:

250281, 250282, 250288

Abstract:

An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to one or more of the plurality of drift tube segments. A control circuit is configured to control operation of the number of electric field activation sources in a manner that sequentially applies electric fields to the drift tube segments to allow only ions having a predefined ion mobility or range of ion mobilities to travel through the drift tube. The drift tube segments may define a linear drift tube or a closed drift tube with a continuous ion travel path. Techniques are disclosed for operating the ion mobility spectrometer to produce highly resolved ion mobility spectra.

US Patent:

8618475, Dec 31, 2013

Filed:

Mar 2, 2011

Appl. No.:

13/038544

Inventors:

David E. Clemmer - Bloomington IN, US
Stormy L. Koeniger - Evanston IL, US
Stephen J. Valentine - Bloomington IN, US

Assignee:

Indiana University Research and Technology Corporation - Indianapolis IN

International Classification:

H01J 49/40

US Classification:

250287, 250282, 250286

Abstract:

An ion mobility spectrometer comprises a drift tube defining a drift tube inlet configured to receive ions and a drift tube outlet. The drift tube is configured to separate ions in time as a function of ion mobility. The drift tube defines a first ion activation region between the drift tube inlet and the drift tube outlet. The first ion activation region is configured to selectively induce structural changes in at least some of the ions.