David Michael Combs

US Patent:

6380393, Apr 30, 2002

Filed:

Mar 19, 1999

Appl. No.:

09/273082

Inventors:

Douglas Bryan Grotjahn - San Diego CA
David Combs - San Diego CA

Assignee:

San Diego State University Foundation - San Diego CA

International Classification:

C07F 1900

US Classification:

548101, 424617, 548112, 5483651, 5483731, 5483751, 5483761, 5483771

Abstract:

Compositions including at least one organic ligand including a first hetero atom and a second hetero atom directly bonded to the first hetero atom or located one carbon atom away from the first hetero atom, with at least one of the hetero atoms being nitrogen, and a transition metal moiety partially complexes by the organic ligand are provided. Such complexes have a controlled adaptable proton transfer ability and/or a hydrogen bonding ability which makes such compositions particularly useful as chemical reaction facilitators. Examples of chemical reactions facilitated by such compositions include hydrolysis reactions and carbon dioxide conversion reactions.

US Patent:

7430822, Oct 7, 2008

Filed:

Jan 3, 2007

Appl. No.:

11/649135

Inventors:

David M. Combs - Newburgh NY, US

International Classification:

G09F 7/00
G09F 13/08

US Classification:

40209, 40544, 40204, 40205

Abstract:

A license plate frame design for providing a thin visually appealing motor vehicle accessory that illuminates advertising text and or a design comprises recessed strip lighting illuminating through recessed color tinted transparent material and through the said advertising test and or said design held or sealed into place by means of a backing plate with a direct current inverter attached by means of lead wires to said motor vehicles controllable direct current power source and to said strip lighting by means of lead wires. Providing the motor vehicle operator to transmit direct current from said motor vehicle when desired, to the said license plate frame to add visual appeal by illuminating their said advertisement and or said design. Thus a very thin and visually appealing motor vehicle accessory is provided.

US Patent:

20140038192, Feb 6, 2014

Filed:

Jul 31, 2013

Appl. No.:

13/956022

Inventors:

David Howard COMBS - San Diego CA, US
Norbert D. HAGEN - Carlsbad CA, US
David OPALSKY - San Diego CA, US
Bruce RICHARDSON - Los Gatos CA, US
Anita PRASAD - Los Gatos CA, US
Keith MORAVICK - Los Gatos CA, US
Tyler MOORE - Los Gatos CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/68

US Classification:

435 612, 4352872

Abstract:

System, apparatus, and method for cycling the temperature of at least one receptacle holder that is adapted for use in an automated instrument capable of performing nucleic acid-based amplification tests. Also provided are methods for conducting automated, random-access incubation processes using the same.

US Patent:

20220349910, Nov 3, 2022

Filed:

Apr 29, 2020

Appl. No.:

17/608745

Inventors:

- San Diego CA, US
HongRan PENG - San Diego CA, US
David Aaron BUSE - San Diego CA, US
David H. COMBS - San Diego CA, US

International Classification:

G01N 35/04
B01L 9/06
B65G 43/08
B65G 47/90
G01N 35/00
G01N 35/10
B01L 3/00

Abstract:

A receptacle delivery system includes a carriage configured to move from a first to a second location of an instrument. The carriage may be configured to removably support a receptacle and may include a receptacle clamping mechanism. The receptacle mechanism may be configured to apply a clamping force to the receptacle as the carriage moves from the first to the second location and release the clamping force as the carriage moves from the second to the first location.

US Patent:

20220291454, Sep 15, 2022

Filed:

Jun 1, 2022

Appl. No.:

17/830115

Inventors:

- San Diego CA, US
David Combs - San Diego CA, US
Norbert D. Hagen - Carlsbad CA, US
David Opalsky - San Diego CA, US
Bruce Richardson - Los Gatos CA, US
Anita Prasad - Los Gatos CA, US
Keith Moravick - Los Gatos CA, US
Tyler Moore - Los Gatos CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

G02B 6/36
G02B 6/06
G02B 6/08
G01N 21/25
G01N 21/64
G02B 6/42

Abstract:

A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature. Signal emissions of receptacles subject to the second thermal cycling process are synchronized with specific temperatures of the second thermal cycling process by comparing time stamps of the second time/signal emission data set for each receptacle with the time stamps of the second time/temperature data set that correspond with the specific temperature.

US Patent:

20210062245, Mar 4, 2021

Filed:

Sep 21, 2020

Appl. No.:

17/027363

Inventors:

- San Diego CA, US
David Howard COMBS - San Diego CA, US
Norbert D. HAGEN - Carlsbad CA, US
David OPALSKY - San Diego CA, US
Bruce RICHARDSON - Los Gatos CA, US
Anita PRASAD - Los Gatos CA, US
Keith MORAVICK - Los Gatos CA, US
Tyler MOORE - Los Gatos CA, US
Byron J. Knight - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/686
B01L 7/00
G01N 21/64

Abstract:

An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.

US Patent:

20210032681, Feb 4, 2021

Filed:

Sep 22, 2020

Appl. No.:

17/028367

Inventors:

- San Diego CA, US
David Howard COMBS - San Diego CA, US
Nobert D. HAGEN - Carlsbad CA, US
David OPALSKY - San Diego CA, US
Bruce RICHARDSON - Los Gatos CA, US
Anita PRASAD - Los Gatos CA, US
Keith MORAVICK - Los Gatos CA, US
Tyler MOORE - Los Gatos CA, US
Byron J. KNIGHT - San Diego CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/686
B01L 7/00
G01N 21/64

Abstract:

Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.

US Patent:

20210017576, Jan 21, 2021

Filed:

Sep 23, 2020

Appl. No.:

17/029930

Inventors:

- San Diego CA, US
David Howard COMBS - San Diego CA, US
Norbert D. HAGEN - Carlsbad CA, US
David OPALSKY - San Diego CA, US
Bruce RICHARDSON - Los Gatos CA, US
Anita PRASAD - Los Gatos CA, US
Keith MORAVICK - Los Gatos CA, US
Tyler MOORE - Los Gatos CA, US

Assignee:

Gen-Probe Incorporated - San Diego CA

International Classification:

C12Q 1/686
B01L 7/00
G01N 21/64

Abstract:

An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.