Richard Desmond - Bridgewater NJ David A. Conlon - Plainsboro NJ Antoinette Drahus - Hoboken NJ Guo-Jie Ho - Scotch Plains NJ Brenda Pipik - Edison NJ Carl Leblond - Gilbertsville PA Anant Vailaya - North Brunswick NJ
Assignee:
Merck Co. Inc. - Rahway NJ
International Classification:
C07D41310
US Classification:
546167, 546172, 546173, 514314, 514311, 514256
Abstract:
A substituted 8-aryl quinoline and its benzenesulfonic acid salt is synthesized.
Removal Of Aldehyde Impurity By Reactive Polystyrene Resini
Mirlinda Biba - Piscataway NJ, US Paul Compton Collins - Bridgewater NJ, US Christopher Joseph Welch - Cranbury NJ, US David A. Conlon - Plainsboro NJ, US Antoinette Drahus - Lexington MA, US
A purification method in the preparation of a substituted 8-arylquinoline, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, utilizes a polystyrene-based sulfonylhydrazine reactive resin to remove an aldehyde impurity.
Process For Making Substituted 8-Arylquinolinium Benzenesulfonate
Richard Desmond - Bridgewater NJ, US David Conlon - Plainsboro NJ, US Antoinette Drahus - Hoboken NJ, US Guo-Jie Ho - Scotch Plains NJ, US Brenda Pipik - Edison NJ, US Carl Leblond - Gilbertsville PA, US Anant Vailaya - North Brunswick NJ, US
International Classification:
C07D413/02
US Classification:
546/176000
Abstract:
A substituted 8-aryl quinoline and its benzenesulfonic acid salt is synthesized.
- Princeton NJ, US David Alan CONLON - New Brunswick NJ, US Paul C. LOBBEN - New Brunswick NJ, US Justin Lockheart BURT - Greenwood IN, US Joshua ENGSTROM - New Brunswick NJ, US Carolyn S. WEI - New Brunswick NJ, US Jason J. ZHU - New Brunswick NJ, US Yu FAN - New Brunswick NJ, US
International Classification:
A61K 31/501 A61K 9/20 A61K 9/48 C07D 217/04
Abstract:
Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and compositions comprising the tetrahydroisoquinolines and other compounds, e.g, intermediates and by-products of the processes described herein. Pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression are also disclosed.
elements, that means its size is guaranteed to be 2 or more. If you add 1/3 to 5/3, your answer is still 2. Its funny, it means that it doesnt actually always improve it, said David Conlon of the California Institute of Technology. Its only when N is divisible by 3 that it improves it.
Rushbrooke School Verdun Kuwait 1953-1954, Riverview School Verdun Kuwait 1955-1961, Woodland Elementary School Verdun Kuwait 1956-1961, St. Willibrord High School Verdun Kuwait 1962-1965