David E Conrad

US Patent:

58248030, Oct 20, 1998

Filed:

Sep 30, 1997

Appl. No.:

8/940736

Inventors:

David W. Conrad - Alexandria VA
Charles H. Patterson - Laurel MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C07F23112
C07F29304
C07D23112

US Classification:

548109

Abstract:

A labeled compound detectable by IR spectroscopy contains at least one hidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm. sup. -1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm. sup. -1.

US Patent:

58470190, Dec 8, 1998

Filed:

Mar 7, 1997

Appl. No.:

8/813144

Inventors:

David W. Conrad - Alexandria VA
Paul T. Charles - Upper Marlboro MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

B32B 2708
G01N 3353
C12M 100
C08F 246

US Classification:

522 2

Abstract:

The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.

US Patent:

61941840, Feb 27, 2001

Filed:

Apr 20, 1999

Appl. No.:

9/294139

Inventors:

David W. Conrad - Alexandria VA
Charles H. Patterson - Laurel MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C12N 999

US Classification:

435184

Abstract:

A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm. sup. -1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm. sup. -1.

US Patent:

57362572, Apr 7, 1998

Filed:

Apr 25, 1995

Appl. No.:

8/428454

Inventors:

David W. Conrad - Alexandria VA
Paul T. Charles - Upper Marlboro MD

International Classification:

B32B 2708
G01N 3353
C12M 100
C08F 246

US Classification:

4284744

Abstract:

The presently claimed invention is directed to novel biochips and a method for forming said biochips and novel photoactivatable compounds, 2,6-DOCA, 2-NOCA and LC-ASA Amine.

US Patent:

57733082, Jun 30, 1998

Filed:

Feb 10, 1997

Appl. No.:

8/797325

Inventors:

David W. Conrad - Alexandria VA
Sara K. Golightley - Alexandria VA
John C. Bart - Alexandria VA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C07C26100
C07C26900
C08F 246
C08J 328

US Classification:

436527

Abstract:

O-nitrobenzyl analogs that include a photoremovable protecting group that resists the nonspecific adsorption of biomolecules and a linking group for attaching the o-nitrobenzyl analog to a substrate are disclosed. Also disclosed are methods for using o-nitrobenzyl analogs for creating patterned arrays of anti-ligands on a substrate so that a plurality of bioassays can be conducted simultaneously. In particular, the compounds disclosed are o-nitrobenzyl-polyethylene glycol-silanes, wherein the silane group serves to attach the compound to a substrate, the polyethylene glycol group resists the nonspecific adsorption of biomolecules. The o-nitrobenzyl group provides a photoactivatable functionality that allows the polyethylene glycol group to be selectively removed upon exposure to UV radiation and be replaced by an anti-ligand.

US Patent:

59225521, Jul 13, 1999

Filed:

Jun 9, 1998

Appl. No.:

9/095025

Inventors:

David W. Conrad - Alexandria VA
Charles H. Patterson - Laurel MD

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

G01N 3353

US Classification:

435 772

Abstract:

A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of 2399-1900 cm. sup. -1. An assay reagent for simultaneously detecting or determining a plurality of different analytes in a sample is made up of a plurality of different labeled compounds, each being independently distinguishable from the others by absorbing energy in a different and distinguishable region in the range of 2300 to 1900 cm. sup. -1.