- Austin TX, US Scott T. YOUNGER - Cambridge MA, US Bethany A. JANOWSKI - Dallas TX, US David R. COREY - Dallas TX, US
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX
International Classification:
C12N 15/63
US Classification:
435 612
Abstract:
Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.