David A Cowburn

age ~80

from New York, NY

Also known as:
  • David E Cowburn
  • David Dr Couburn
  • David A Couburn
  • David Stoner
  • David S Toner
  • Adam Cowburn
  • Elizabet Cowburn
  • David Coburn

David Cowburn Phones & Addresses

  • New York, NY
  • Westfield, NJ
  • Hanover, NH

Us Patents

  • Method For The Comparative Quantitative Analysis Of Proteins And Other Biological Material By Isotopic Labeling And Mass Spectroscopy

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  • US Patent:
    6391649, May 21, 2002
  • Filed:
    May 4, 1999
  • Appl. No.:
    09/304799
  • Inventors:
    Brian T. Chait - N.Y. NY
    David Cowburn - Westfield NJ
    Yoshi Oda - Ibaraki, JP
  • Assignee:
    The Rockefeller University - New York NY
  • International Classification:
    G01N 3100
  • US Classification:
    436173, 436174, 436177
  • Abstract:
    The present invention is a method for accurately comparing the levels of cellular components, such as proteins, present in samples which differ in some respect from each other using mass spectroscopy and isotopic labeling. A first sample of biological matter, such as cells, is cultured in a first medium and a second sample of the same biological matter is cultured in a second medium, wherein at least one isotope in the second medium has a different abundance than the abundance of the same isotope in the first medium. One of the samples is modulated, such as by treatment with a bacteria, a virus, a drug, hormone, a chemical or an environmental stimulus. The samples are combined and at least one protein is removed. The removed protein is subjected to mass spectroscopy to develop a mass spectrum. A ratio is computed between the peak intensities of at least one closely spaced pair of peaks to determine the relative abundance of the protein in each sample.
  • Method For The Comparative Quantitative Analysis Of Proteins And Other Biological Material By Isotopic Labeling And Mass Spectroscopy

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  • US Patent:
    6642059, Nov 4, 2003
  • Filed:
    Sep 6, 2001
  • Appl. No.:
    09/949510
  • Inventors:
    Brian T. Chait - N.Y. NY
    David Cowburn - Westfield NJ
    Yoshi Oda - Ibaraki, JP
  • Assignee:
    The Rockefeller University - New York NY
  • International Classification:
    G01N 2400
  • US Classification:
    436173, 436174, 436177
  • Abstract:
    The present invention is a method for accurately comparing the levels of cellular components, such as proteins, present in samples which differ in some respect from each other using mass spectroscopy and isotopic labeling. A first sample of biological matter, such as cells, is cultured in a first medium and a second sample of the same biological matter is cultured in a second medium, wherein at least one isotope in the second medium has a different abundance than the abundance of the same isotope in the first medium. One of the samples is modulated, such as by treatment with a bacteria, a virus, a drug, hormone, a chemical or an environmental stimulus. The samples are combined and at least one protein is removed. The removed protein is subjected to mass spectroscopy to develop a mass spectrum. A ratio is computed between the peak intensities of at least one closely spaced pair of peaks to determine the relative abundance of the protein in each sample.
  • Methods And Devices For Characterizing Macromolecular Complexes Using Isotope Labeling Techniques

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  • US Patent:
    20060183157, Aug 17, 2006
  • Filed:
    Feb 7, 2006
  • Appl. No.:
    11/350176
  • Inventors:
    David Cowburn - Westfield NJ, US
    Kaushik Dutta - New York NY, US
    Fabien Ferrage - New York NY, US
    Alexander Shekhtman - Albany NY, US
  • International Classification:
    G01N 33/53
    G06F 19/00
  • US Classification:
    435007100, 702019000
  • Abstract:
    A method for characterizing interactions in macromolecular complexes, such as protein-protein or protein-ligand complexes, by selective isotopic labeling of the target molecule to reduce the H density in a selected spectral region; by irradiating the target; and by monitoring the polarization using filtered nuclear Overhauser spectroscopy (NOESY) and/or by performing selective saturation transfer experiments to determine the docking potential of the macromolecular complex.
  • Peptides Specific For The First Crk-Sh3 Domain

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  • US Patent:
    58887636, Mar 30, 1999
  • Filed:
    Dec 30, 1994
  • Appl. No.:
    8/367070
  • Inventors:
    Beatrice S. Knudsen - New York NY
    Stephan M. Feller - New York NY
    John Kuriyan - New York NY
    Xiaodong Wu - New York NY
    Jie Zheng - New York NY
    David Cowburn - Westfield NJ
  • Assignee:
    The Rockefeller University - New York NY
  • International Classification:
    C12P 2106
    C12N 120
    C07H 2100
  • US Classification:
    435 691
  • Abstract:
    The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.
  • Method Of Determining Interdomain Orientation And Changes Of Interdomain Orientation On Ligation

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  • US Patent:
    61718041, Jan 9, 2001
  • Filed:
    Jul 12, 1999
  • Appl. No.:
    9/351570
  • Inventors:
    David Cowburn - Westfield NJ
    Rong Xu - Tarrytown NY
    David Fushman - New York NY
  • Assignee:
    The Rockefeller University - New York NY
  • International Classification:
    G01N 3353
    G01N 33566
    G01N 33557
  • US Classification:
    435 71
  • Abstract:
    The present invention provides methods for determining the relative orientation of the individual components of a macromolecule in solution with respect to the global molecular coordinate frame of the macromolecule. The present invention further provides methods for applying this structural information, including for rational drug design.
  • Atypical Split Inteins And Uses Thereof

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  • US Patent:
    20220275027, Sep 1, 2022
  • Filed:
    Aug 28, 2019
  • Appl. No.:
    17/753299
  • Inventors:
    - Princeton NJ, US
    - Bronx NY, US
    JOSEF GRAMESPACHER - Princeton NJ, US
    DAVID COWBURN - Bronx NY, US
    GIRIDHAR SEKAR - Bronx NY, US
  • International Classification:
    C07K 14/00
    C07K 1/02
  • Abstract:
    The present disclosure relates to atypical split N- and C-inteins and variants thereof. This disclosure also relates to complexes comprising the split N- or C-inteins of this disclosure and a compound of interest and compositions comprising said complexes. In addition, this disclosure relates to methods of using the atypical split N- and C-inteins.

Resumes

David Cowburn Photo 1

Professor

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Location:
Bronx, NY
Industry:
Research
Work:
New York Structural Biology Center
Member Board of Directors

Coferon Jun 2009 - Nov 2010
Sab Member

Albert Einstein College of Medicine Jun 2009 - Nov 2010
Professor

New York Structural Biology Center Sep 2000 - Aug 2010
President and Ceo; Head, Lab Physical Biochemistry

Rockefeller University 1972 - 2001
Faculty
Education:
King's College London 1981 - 1981
Columbia University Vagelos College of Physicians and Surgeons 1970 - 1973
King's College London 1965 - 1970
Doctorates, Doctor of Philosophy, Biophysics
The University of Manchester 1962 - 1965
Manchester Grammar School 1956 - 1962
Skills:
Structural Biology
Biophysics
Biochemistry
Molecular Biology
Nmr
Protein Chemistry
Science
Bioinformatics
Life Sciences
Cell Biology
Signal Transduction
Protein Purification
Drug Discovery
Protein Expression
Lifesciences
Chemistry
Spectroscopy
Homology Modeling
Fluorescence
X Ray Crystallography
Computational Biology
Cancer
Pharmacology
Molecular Cloning
Molecular Modeling
Pcr
Purification
Nuclear Magnetic Resonance
Interests:
Civil Rights and Social Action
Education
Science and Technology
Human Rights
Health
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David Cowburn

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David Cowburn Photo 3

David Cowburn

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Name / Title
Company / Classification
Phones & Addresses
David Cowburn
President
New York Structural Biology
Other Social Advocacy Organizations
89 Convent Ave, New York, NY 10027
2129268548, 2129390863
David Cowburn
President
New York Structural Biology Center Inc
Commercial Physical Research
89 Convent Ave, New York, NY 10027
2129390660, 2129268548

Youtube

DAVID COWBURN - STUDIO ONE YOGA

Trailer Video for the full Spotlight On Video at .

  • Duration:
    47s

Funeral Directors - David Cowburn Funeral Dir...

  • Duration:
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David Cowburn - Studio One Yoga

We love hearing from our students and finding out how yoga affects the...

  • Duration:
    3m 19s

194: How To Crush Negative Thoughts: Jumping ...

Today, the Cognitive Distortion Starter Kit Continues with Jumping to ...

  • Duration:
    52m 6s

England's Highest Yoga Class

On Sunday 21st July a group of students followed their leader, David C...

  • Duration:
    1m 48s

18 Brad Green vs Ronnie Cowburn

D-DAY XVII A night of top class boxing and entertainment at The Fed, D...

  • Duration:
    8m 34s

Classmates

David Cowburn Photo 4

North Syracuse High Schoo...

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Graduates:
Shannon Labrake (1991-1995),
Stanley Lemko (1960-1960),
David Cowburn (1965-1969),
Roderick Henry (1966-1970)

Googleplus

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Facebook

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David Cowburn

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Friends:
Richard Thompson, Stuart Tomlinson, Alastair Cairns, Chris Leigh

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