David L Devlin

US Patent:

20090192135, Jul 30, 2009

Filed:

Mar 28, 2006

Appl. No.:

11/887346

Inventors:

Jason Samuel Simon - Westfield NJ, US
Maha Chabhar Karnoub - Doylestown PA, US
Michael E. Severino - Westlake Village CA, US
David James Devlin - New City NY, US
Andrew Stewart Plump - Westfield NJ, US
Eric E. Schadt - Kirkland WA, US

Assignee:

SCHERING CORPORATION - Kenilworth NJ
MERCK & CO., INC. - Rahway NJ
ROSETTA INPHARMATICS LLC - Seattle WA

International Classification:

A61K 31/397
C12Q 1/60
C12Q 1/68
C40B 30/04
C07H 21/04

US Classification:

51421002, 435 11, 435 6, 506 9, 536 235

Abstract:

The present invention relates to the identification and use of single nucleotide polymorphisms and haplotypes in the Niemann Pick C1-Like 1 (NPC1L1) gene. In particular, methods are provided for correlating NPC1L1 polymorphisms and haplo-types with the responsiveness of a pharmaceutically active compound administered to a human subject. The invention further relates to a method for estimating the responsiveness of a pharmaceutically active compound administered to a human subject which method comprises determining at least one polymorphism in the NPC1L1 gene. The methods are based on determining polymorphisms in the NPC1L1 gene and correlating the responsiveness of a pharmaceutically active compound in the human by reference to one or more polymorphism in NPC1L1. The invention further relates to isolated nucleic acids comprising within their sequence the polymorphisms as defined herein, to nucleic acid primers and oligonucleotide probes capable of hybridizing to such nucleic acids and to a diagnostic kit comprising one or more of such primers and probes for detecting a polymorphism in the NPC1L1 gene.