David D Duffy

US Patent:

20100093719, Apr 15, 2010

Filed:

Sep 30, 2009

Appl. No.:

12/570153

Inventors:

Stewart CAMPBELL - Framingham MA, US
David DUFFY - Somerville MA, US
Michael GROGAN - Winchester MA, US
Steven KATES - Needham MA, US
Emanuele OSTUNI - Lexington MA, US
Olivier SCHUELLER - Arlington MA, US
Paul SWEETNAM - Marblehead MA, US

Assignee:

SURFACE LOGIX, INC. - Brighton MA

International Classification:

A61K 31/53
C07D 487/04
A61P 15/00
A61K 31/5377

US Classification:

5142332, 544184, 544112, 514243

Abstract:

A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided:or pharmaceutically acceptable salt, stereoisomer, or hydrate thereof, wherein Ris lower alkyl, Rand Rare independently selected from lower alkyl, and lower alkenyl and lower alkynyl, wherein the lower alkyl, lower alkenyl, and lower alkynyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO, amino, acylamino, amido, carbonyl, and alkylthio, A is N or C—H, B is N, C—H, C—(SO—R), or C—CO—R, D is N, C—H, C—(SO—R) or C—CO—R, E is N or C—H, wherein only one of A, B or E may be N, and one of B or D is C—(SO—R) or C—CO—R, Ris a group having the formula:in which each R, R, Rand Rare independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO, amino, acylamino, amido, carbonyl, and alkylthio; and additionally or alternatively Rand Rtogether form a 5- or 6-membered ring, or Rand Rtogether form a 3 to 6 membered ring; Ris independently selected from H and lower alkyl, wherein the lower alkyl may be optionally substituted with one or more halogen, lower alkoxy, hydroxy, CN, NO, amino, acylamino, amido, carbonyl, and alkylthio; alternatively Rand Rtogether with the nitrogen to which they are attached form a 5- or 6-membered ring; n is 1 to 4; and m is 1 to 6.

US Patent:

20100324037, Dec 23, 2010

Filed:

Aug 23, 2007

Appl. No.:

12/438504

Inventors:

Stewart Campbell - Framingham MA, US
David Duffy - Somerville MA, US
Michael Grogan - Winchester MA, US
Steven Kates - Needham MA, US
Emanuele Ostuni - Lexington MA, US
Olivier Schueller - Arlington MA, US
Paul Sweetnam - Marblehead MA, US

Assignee:

SURFACE LOGIX, INC. - Brighton MA

International Classification:

A61K 31/5377
C07D 487/04
A61K 31/53
A61P 9/12
A61P 15/10

US Classification:

5142332, 544184, 514243, 544112

Abstract:

A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided:or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

US Patent:

20110172422, Jul 14, 2011

Filed:

Feb 21, 2006

Appl. No.:

11/884811

Inventors:

Stewart Campbell - Framingham MA, US
David Duffy - Somerville MA, US
Michael Grogan - Winchester MA, US
Steven Kates - Needham MA, US
Emanuele Ostuni - Lexington MA, US
Olivier Schueller - Arlington MA, US
Paul Sweetnam - Marblehead MA, US

Assignee:

SURFACE LOGIX, INC. - Brighton MA

International Classification:

C07D 487/04

US Classification:

544184

Abstract:

The present invention relates to methods of modulating the pharmacokinetic and/or pharmacodynamic properties of a compound by attaching at least one functional unit or group to the compound, thereby improving its non-specific binding characteristics and/or pharmacokinetic properties. Compounds comprising at least one functional residue are provided, as are pharmaceutical compositions comprising said compounds.

US Patent:

20120196774, Aug 2, 2012

Filed:

Feb 25, 2011

Appl. No.:

13/035472

Inventors:

David Fournier - Northborough MA, US
Todd Campbell - Holliston MA, US
Cheuk Kan - Boston MA, US
John Lawson - Petersham MA, US
Andrew Rivnak - Somerville MA, US
Michael Kagan - Sebec ME, US
David C. Duffy - Somerville MA, US

Assignee:

Quanterix Corporation - Cambridge MA

International Classification:

C40B 50/18
B05D 5/10
C40B 60/14
C40B 60/12
C40B 60/00

US Classification:

506 32, 506 39, 506 33, 506 40, 4272071, 156145

Abstract:

Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

US Patent:

20130165342, Jun 27, 2013

Filed:

Feb 15, 2013

Appl. No.:

13/768843

Inventors:

David Fournier - Northborough MA, US
David C. Duffy - Somerville MA, US

Assignee:

Quanterix Corporation - Lexington MA

International Classification:

G01N 33/50

US Classification:

506 9, 422 69, 436518, 435 79, 4352871, 506 39

Abstract:

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

US Patent:

20210311058, Oct 7, 2021

Filed:

Mar 23, 2021

Appl. No.:

17/210258

Inventors:

- Billerica MA, US
David Fournier - Northborough MA, US
David C. Duffy - Arlington MA, US

Assignee:

Quanterix Corporation - Billerica MA

International Classification:

G01N 33/573
G01N 21/64
G01N 33/543

Abstract:

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

US Patent:

20180306830, Oct 25, 2018

Filed:

Mar 14, 2018

Appl. No.:

15/921429

Inventors:

- Lexington MA, US
Todd Campbell - Holliston MA, US
Cheuk Kan - Waltham MA, US
John Lawson - Petersham MA, US
Andrew Rivnak - Somerville MA, US
Michael Kagan - Sebec ME, US
David C. Duffy - Arlington MA, US

Assignee:

Quanterix Corporation - Lexington MA

International Classification:

G01N 35/00
B01L 3/00
G01N 35/10

Abstract:

Described are systems, devices, and methods which related to various aspects of assays for detecting and/or determining a measure of the concentration of analyte molecules or particles in a sample fluid. In some cases, the systems employ an assay consumable comprising a plurality of assay sites. The systems, devices, and/or methods, in some cases, are automated. In some cases, the systems, devices, and/or methods relate to inserting a plurality of beads into assay sites, sealing assay sites, imaging assay sites, or the like.

US Patent:

20180224451, Aug 9, 2018

Filed:

Nov 10, 2017

Appl. No.:

15/808969

Inventors:

- Lexington MA, US
David Fournier - Northborough MA, US
David C. Duffy - Arlington MA, US

Assignee:

Quanterix Corporation - Lexington MA

International Classification:

G01N 33/573
G01N 33/543
G01N 21/64

Abstract:

Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.