David Alan Fink

US Patent:

6835377, Dec 28, 2004

Filed:

May 13, 1998

Appl. No.:

09/078531

Inventors:

Victor M. Goldberg - Gates Mills OH
Arnold I. Caplan - Cleveland Heights OH
Francis P. Barry - Baltimore MD
David J. Fink - Baltimore MD
Daniel R. Marshak - Lutherville MD
James S. Burns - Annapolis MD

Assignee:

Osiris Therapeutics, Inc. - Baltimore MD

International Classification:

C12N 500

US Classification:

424 937, 435366, 435372

Abstract:

For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) broaden the suitable clinical population to routinely include middle-aged patients; (3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; (4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; (5) regenerate articular joint cartilage in older patients with osteoarthritis; and (6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.

US Patent:

8580749, Nov 12, 2013

Filed:

Jun 7, 2010

Appl. No.:

12/795195

Inventors:

Joseph Wagner - Shaker Heights OH, US
Randell Young - Ellicott City MD, US
David Fink - Baltimore MD, US

Assignee:

Cell Targeting, Inc. - Alameda CA

International Classification:

A61K 38/08

US Classification:

514 217, 514 11, 514 218, 424 931

Abstract:

Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.

US Patent:

20090274712, Nov 5, 2009

Filed:

Oct 24, 2007

Appl. No.:

12/446836

Inventors:

James E. Dennis - Cleveland Heights OH, US
Arnold I. Caplan - Cleveland Heights OH, US
David J. Fink - Baltimore MD, US

International Classification:

A61K 39/44
A61K 45/00
A61P 35/00

US Classification:

4241781, 424 937

Abstract:

In certain aspects, the invention relates to cell delivery compositions comprising a progenitor cell and a targeting moiety, and methods related thereto. Such compositions and methods may be used, for example, in administering a targeted cell therapy cell therapy to a subject.

US Patent:

57118531, Jan 27, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/479696

Inventors:

Kevin M. Virnelson - Mayfield Hts. OH
Kenneth E. Hughes - Gahanna OH
David C. Masterson - Grove City OH
David J. Fink - Shaker Heights OH
Barbara A. Metz - Baltimore OH
Gordon E. Pickett - Reynoldsburg OH
Paul M. Gemmer - Columbus OH
Richard S. Brody - Worthington OH

Assignee:

Ranpak Corp. - Concord OH

International Classification:

D21H 1700
D21H 1722

US Classification:

162143

Abstract:

A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.

US Patent:

55100660, Apr 23, 1996

Filed:

Oct 4, 1994

Appl. No.:

8/317892

Inventors:

David J. Fink - Shaker Heights OH
Thomas J. Ward - Columbus OH
Joel C. Preston - Grove City OH

Assignee:

Guild Associates, Inc. - Columbus OH

International Classification:

B29C 4102
B29C 4152

US Classification:

264 401

Abstract:

A preparing of a self-supporting or free-standing three-dimensional unitary structural body by a method including generating successively a plurality of cross-sectional layers of the body, one layer top of the other and with the layers joined together to form the body and with the generating of a cross-sectional layer comprising placing a plurality of drops of a liquid composition, containing a first reactant, in a pattern of discrete drops making up the cross-sectional layer and subsequently placing a plurality of discrete drops of other liquid composition, containing another reactant, in contact with the placed drops ion the pattern so that the first reactant and the other reactant react to provide a solid.

US Patent:

53169425, May 31, 1994

Filed:

Jun 16, 1993

Appl. No.:

8/078932

Inventors:

David J. Fink - Shaker Heights OH

Assignee:

Battelle Memorial Institute - Columbus OH

International Classification:

C07K 312
C12P 2100
C12N 999
A61K 3712

US Classification:

435273

Abstract:

The invention includes a method that produces a low cost aqueous solution of high molecular weight solubilized collagen by the steps of: (a) providing an aqueous ground slurry of insoluble collagen; (b) adjusting the water or solid content of the wet ground slurry whereby the insoluble collagen is at a concentration that promotes substantially maximum solubilized collagen concentration and molecular weight in a final product; (c) adjusting the pH of the slurry from Step b to obtain activity for a proteolytic enzyme added in Step d; (d) adding the proteolytic enzyme to the pH adjusted slurry and reacting at a temperature, T, and for a time, t, effective for forming high molecualr weight solubilized collagen from the insoluble collagen particles; (e) controlling the reaction conditions for obtaining a high concentration of soluble collagen and a high molecular weight of the solubilized collagen by simultaneously measuring the concentration of solubilized collagen and the molecular weight of the solubilized collagen, whereby the reaction is complete when the molecular weight and the concentration are substantially maximized; and (f) withdrawing the aqueous solution of high molecular weight solubilized collagen as product. Proteolytic enzyme recycle steps are disclosed that can be used to further reduce costs.

US Patent:

58109706, Sep 22, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/478548

Inventors:

Kenneth E. Hughes - Gahanna OH
David C. Masterson - Grove City OH
David J. Fink - Shaker Heights OH
Barbara A. Metz - Baltimore OH
Gordon E. Pickett - Reynoldsburg OH
Paul M. Gemmer - Columbus OH

Assignee:

Ranpak Corporation - Concord OH

International Classification:

D21H 1700
D21H 1722

US Classification:

162143

Abstract:

A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; forming the interacted cellulosic pulp slurry and solubilized collagen into a sheet; and drying the sheet; also, a method for using solubilized collagen for strengthening paper by mixing the solubilized collagen with a cellulosic pulp slurry; and making a cellulosic pulp product from the mixture and drying.

US Patent:

45116253, Apr 16, 1985

Filed:

Sep 30, 1982

Appl. No.:

6/429186

Inventors:

Faramarz Nazem - Strongsville OH
Rostislav Didchenko - Middleburg Heights OH
David Fink - Stamford CT

Assignee:

Union Carbide Corporation - Danbury CT

International Classification:

C10C 318
D01F 914
D01D 104
D01D 508

US Classification:

428401

Abstract:

A process of spinning a pitch having less than 40% by weight mesophase into a pitch fiber having at least 70% by weight mesophase is described.