David S Friend

US Patent:

56562942, Aug 12, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/486974

Inventors:

David R. Friend - Menlo Park CA
David Wong - San Francisco CA

Assignee:

Cibus Pharmaceutical, Inc. - Redwood City CA

International Classification:

A61K 920
A61K 3156
A61K 4736

US Classification:

424465

Abstract:

Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition comprises about 0. 5% by weight to about 10% by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40% by weight to about 80% by weight of a hydrocolloid gum obtainable from higher plants; and about 10% by weight to about 50% by weight of a pharmaceutically acceptable binder. The compositions are useful for treating colon disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet.

US Patent:

60634022, May 16, 2000

Filed:

Jun 7, 1995

Appl. No.:

8/487605

Inventors:

Mark S. Gebert - East Palo Alto CA
David R. Friend - Menlo Park CA
David Wong - San Francisco CA
Jagdish Parasrampuria - San Mateo CA

Assignee:

Venture Lending, A Division of Cupertino National Bank - Palo Alto CA

International Classification:

A61K 920
C07M 100

US Classification:

424464

Abstract:

Disclosed is a substantially anhydrous, powdered, galactomannan composition consisting essentially of a galactomannan hydrocolloid exhibiting about 50% to about 90% by weight of anhydromannose residues and about 10% to about 50% by weight anhydrogalactose residues; less than about 1% by weight of protein material and less than about 3% of other nonaqueous impurities. This material is useful for preparing pharmaceutical compositions both in the substantially anhydrous form but preferably in an anhydrated form which includes about 5-15% by weight water. The pharmaceutical compositions comprise a therapeutically effective amount of a drug, the hydrated powered gallactomannan composition and optionally other pharmaceutically-acceptable excipients. When the hydrated powdered purified glactomannan of the invention is used to form a tablet, one sees improved hardness in the tablet formed. The pharmaceutical composition of the invention is particularly valuable for delivering a therapeutically effective drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition.

US Patent:

58113886, Sep 22, 1998

Filed:

Feb 16, 1996

Appl. No.:

8/602611

Inventors:

David R. Friend - Menlo Park CA
David Wong - San Francisco CA

Assignee:

Cibus Pharmaceutical, Inc. - Burlingame CA

International Classification:

A61K 924
A61K 934
A61K 936
A61K 3800

US Classification:

514 2

Abstract:

Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition is a unit dosage in the form of a tablet that comprises about 0. 01% by weight to about 10% by weight of the drug that is useful in treating a colonic disorder or that is absorbed from the colon; about 40% by weight to about 98% by weight of a hydrocolloid gum obtainable from higher plants; and about 2% by weight to about 50% by weight of a pharmaceutically acceptable binder. The compositions are useful for treating lower GI disorders in human subjects by administering a suitable amount to a subject in need thereof. A particularly preferred aspect is the process for preparing such composition in the form of a tablet.

US Patent:

61398659, Oct 31, 2000

Filed:

Oct 1, 1997

Appl. No.:

8/942094

Inventors:

David R. Friend - Menlo Park CA
Steve Ng - San Francisco CA
Rafael E. Sarabia - Chester NJ
Thomas P. Weber - Shoreview MN
Jean-Marie Geoffroy - Grayslake IL

Assignee:

Eurand America, Inc. - Vandalia OH

International Classification:

A61K 920
A61K 950
A61K 958
A61K 962

US Classification:

424441

Abstract:

A taste-masked microcapsule composition for administration of a drug is provided. The composition comprises microcapsules of drug and a substantially water-insoluble polymeric material, typically a cellulosic polymer. The microcapsule composition may be incorporated into any number of pharmaceutical formulations, including chewable tablets, effervescent tablets, powders, liquid dispersions, and the like. A method for masking the taste of drugs is also provided, involving a phase separation coacervation technique in which drug is coated with relatively high levels of a polymeric material. These high coating levels give rise to effective taste masking, while nevertheless allowing targeted release of drug, so that the drug is released shortly after passage through the mouth.

US Patent:

50911228, Feb 25, 1992

Filed:

Mar 24, 1988

Appl. No.:

7/173071

Inventors:

David R. Friend - Menlo Park CA

Assignee:

Idemitsu Kosan Company, Ltd. - Tokyo

International Classification:

B01J 1304

US Classification:

264 433

Abstract:

A method of preparing microencapsulated basic solutions including the steps of preparing a polymer which is hydrophobic at high pH values, preparing a basic solution, dissolving the polymer in an organic solvent, adding a surfactant to the polymer solution, adding the basic solution to the dissolved polymer, emulsifying the basic solution and dissolved polymer and spray drying the emulsion while stirring the emulsion.

US Patent:

52389332, Aug 24, 1993

Filed:

Apr 2, 1992

Appl. No.:

7/862387

Inventors:

Paul G. Catz - Palo Alto CA
David R. Friend - Menlo Park CA
Harold W. Nolen - San Jose CA

Assignee:

SRI International - Menlo Park CA

International Classification:

B01J 2108

US Classification:

5142362

Abstract:

Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The compositions contain a lower aliphatic ester of a lower aliphatic carboxylic acid such as ethyl acetate and a lower alkanol such as propylene glycol. Methods and transdermal drug delivery systems for using the compositions are also provided.

US Patent:

51125412, May 12, 1992

Filed:

Jan 29, 1988

Appl. No.:

7/150056

Inventors:

David R. Friend - Menlo Park CA

Assignee:

Idemitsu Kosan Company, Ltd. - Tokyo

International Classification:

B01J 1318
B01J 1302

US Classification:

264 47

Abstract:

Microencapsulating lubricating fluids and additives and a method of preparing microencapsulated lubricants including the steps of preparing an emulsification medium, adding a lubricant to the emulsification medium, emulsifying the emulsification medium and lubricant to form an emulsion, adding a first solution including resorcinol and dimethylol urea to the emulsion, acidifying the first solution and emulsion, adding a second solution consisting of resorcinol and dimethylol urea to the acidified first solution and emulsion while vigorously stirring it to form a microcapsule suspension, adjusting the pH to be basic, filtering and washing the microcapsule suspension to separate the microcapsules from the solution, and drying the microcapsules.

US Patent:

59938609, Nov 30, 1999

Filed:

Nov 13, 1997

Appl. No.:

8/969810

Inventors:

Eric H. Kuhrts - Woodside CA
David R. Friend - Menlo Park CA
Karen Yu - Sunnyvale CA
Jagdish Parasrampuria - San Mateo CA

Assignee:

Venture Lending - Palo Alto CA

International Classification:

A61K 916
A61K 4730
A61K 4736

US Classification:

424500

Abstract:

An oral-delivery pharmaceutical composition for reducing the gastric irritation effect of an NSAID in the upper GI tract of a mammal. The composition includes (a) a mucosal protective amount of a pharmaceutically-acceptable hydrocolloid gum obtainable from higher plants, (b) a dispersion-enhancing amount of another excipient and (c) a therapeutically-effective amount of an NSAID. Also disclosed is a process for preparing the composition and a method for reducing the gastric irritation effect of the NSAID by administering the composition. Also, disclosed is a composition particularly useful for preparing an aqueous suspension.