David M Garrison

US Patent:

20140377319, Dec 25, 2014

Filed:

Apr 18, 2012

Appl. No.:

14/112817

Inventors:

Eric C. Leuthardt - St. Louis MO, US
Daniel W. Moran - St. Louis MO, US
David Holtzman - St. Louis MO, US
Philip Bayly - St. Louis MO, US
David Brody - St. Louis MO, US
Ralph G. Dacey - St. Louis MO, US
Sam Fok - St. Louis MO, US
David Jeremiah Garrison - Charlottesville VA, US
Guy M. Genin - St. Louis MO, US
Eriks Lusis - St. Louis MO, US
Rohit Pappu - St. Louis MO, US
Jingwei Xie - Chesapeake OH, US
Greg Zipfel - University City MO, US

Assignee:

WASHINGTON UNIVERSITY - St. Louis MO

International Classification:

A61K 38/48
A61K 9/00
A61K 47/48
C12N 11/08

US Classification:

424422, 435180, 435268, 424 9467

Abstract:

Devices and methods of altering protein concentrations in cerebrospinal fluid and/or brain interstitial fluid are disclosed. Devices include a support having at least one protease attached to the support. The device may further include a housing. Devices may be implantable for use in an in vivo active flow system or for use in an in vivo passive system. Devices may also be used in an ex vivo active flow system. Devices may also be used in a passive system to treat cerebrospinal fluid and/or brain interstitial fluid that is withdrawn, or in a passive system that is implanted surgically. Methods include contacting cerebrospinal fluid and/or brain interstitial fluid with a support including at least one protease attached to the support. Proteins contained in the cerebrospinal fluid and/or brain interstitial fluid are cleaved by the protease resulting in the reduction of protein in cerebrospinal fluid and/or brain interstitial fluid. Additionally, methods are disclosed for treating neurodegenerative diseases and neurological disorders.