David A Gibbs

US Patent:

58174753, Oct 6, 1998

Filed:

Nov 15, 1996

Appl. No.:

8/746734

Inventors:

David L. Gibbs - New York NY
Wei-Fang Hsia - Bayside NY
Qi Wang - New York NY

Assignee:

Giles Scientific, Inc. - New York NY

International Classification:

C12Q 102

US Classification:

435 29

Abstract:

A microbiological assay investigatory apparatus has a source of electromagnetic waveform energy, a support and a linear color sensor. The support serves to hold a microbiological assay tray in a predetermined location relative to the source and to the sensor. The assay tray has different reaction chemicals and microorganisms of the same type in respective wells or chambers. The linear color sensor is disposed in a predetermined position relative to the support and concomitantly the assay tray for receiving electromagnetic waveform radiation emanating from a linear array of the wells in response to waveform energy from the source. The linear color sensor generates a signal encoding colorimetric data pertaining to a series of samples lying along a line intersecting the linear array of the wells.

US Patent:

48333824, May 23, 1989

Filed:

Jun 6, 1986

Appl. No.:

6/871531

Inventors:

David L. Gibbs - New York NY

International Classification:

G05B 106

US Classification:

318640

Abstract:

In a method for visually inspecting a sample through an objective lens of a microscope, a slide carrier attached to the microscope stage is automatically shiftable relative to a frame and to the stage along a predetermined meander path. A microscope slide and the slide carrier are provided with cooperating elements for positioning the slide at a predetermined position and orientation with respect to the carrier. The slide is further provided with a reference mark for enabling an automatic monitoring of the position of the slide relative to the frame of the carrier during an inspection of the slide. The x and y coordinates relative to the slide carrier frame of a detected microscopic object are recorded. On a later occasion, the detected object can be easily relocated by fixing the slide to the carrier in the predetermined fixed position and orientation, shifting the slide carrier so that the reference mark appears in the visual field of the microscope being used, setting this position of the slide as a reference position, and moving the slide as well as the slide carrier from that reference position in accordance with the previously recorded x and y coordinates.

US Patent:

50005545, Mar 19, 1991

Filed:

May 23, 1990

Appl. No.:

7/527300

Inventors:

David L. Gibbs - New York NY

International Classification:

G02B 2126
G02B 2736

US Classification:

350529

Abstract:

An assembly for use with an optical microscope in visually detecting the presence of a microscopic object in a sample and determining the position of the object in the sample to enable repeated visual observation of the object, the microscope having a microscope stage and an objective lens system with an optical path, comprises a slide holder removably attachable to the microscope stage in a plurality of alternative positions with respect to the stage for movably holding a slide bearing the sample, the slide holder including a frame stationary with respect to the stage and a slide carrier automatically shiftable with respect to the frame and the stage. The assembly further comprises a drive operatively connected to the slide holder for shifting the carrier and the slide carried thereby along a search path to enable a visual inspection of the sample. Mounting elements are provided on the carrier for mounting the slide to the carrier and for positioning the slide at a predeterminable fixed position and orientation with respect to the carrier. A monitoring device is operatively connected to the slide holder and to the drive for measuring changes in the position of the carrier relative to the frame and signaling the drive as to the measured changes in the position of the carrier.

US Patent:

47018500, Oct 20, 1987

Filed:

Jun 26, 1985

Appl. No.:

6/749006

Inventors:

David L. Gibbs - New York NY

International Classification:

G06F 1542

US Classification:

364415

Abstract:

An apparatus for using the continuous-gradient disk diffusion technique to obtain quantitative minimum inhibitory concentrations and inhibitory quotients comprises an electronic caliper operatively coupled to a microprocessor for feeding thereto signals coding the diameters of bacteria-growth inhibition zones measured by the caliper. In response to the signals, the microprocessor automatically calculates by means of a regression-type analysis the minimum inhibitory concentrations of the drugs, as determinable based on a correlation with results by a broth dilution test, with respect to the bacterium under study. The microprocessor also calculates, in response to the signals from the electronic caliper, inhibitory quotients with respect to a plurality of different body fluids such as bile, blood and cortical spinal fluid. The apparatus may also be used to determine unknown concentrations of antimicrobial drugs by using the disk diffusion technique and a regression analysis.

US Patent:

46614931, Apr 28, 1987

Filed:

Mar 6, 1986

Appl. No.:

6/837658

Inventors:

David L. Gibbs - New York NY

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 3150
A61K 31415
A61K 31445
A61K 31495

US Classification:

514252

Abstract:

Topical vaginal forms of tioconazole and related antimicrobic compounds, especially miconazole, econazole, clotrimazole, butaconazole and ketoconazole, are useful for the control (chemotherapeutic and chemoprophylactic) of Herpes virus infections.