David T Griffith

US Patent:

6372743, Apr 16, 2002

Filed:

Sep 29, 2000

Appl. No.:

09/676970

Inventors:

James W. Darrow - Wallingford CT
Stephane De Lombaert - Madison CT
Charles Blum - Westbrook CT
Jennifer Tran - Guilford CT
Mark Giangiordano - Branford CT
David Andrew Griffith - Old Saybrook CT
Philip Albert Carpino - Groton CT

Assignee:

Neurogen Corporation - Branford CT
Pfizer Inc. - New York NY

International Classification:

A61K 3153

US Classification:

514246, 514245, 514258, 544194, 544197, 544198, 544204, 544206, 544209, 544211, 544212, 544263, 544281

Abstract:

Disclosed are compounds of the formula: where R , R , R , R , R , R , and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.

US Patent:

6476038, Nov 5, 2002

Filed:

Sep 29, 2000

Appl. No.:

09/676972

Inventors:

James W. Darrow - Wallingford CT
Charles Blum - Westbrook CT
Jennifer Tran - Guilford CT
Mark Giangiordano - Branford CT
David Andrew Griffith - Old Saybrook CT
Philip Albert Carpino - Groton CT

Assignee:

Neurogen Corporation - Branford CT
Pfizer Inc. - New York NY

International Classification:

C07D48704

US Classification:

514258, 544281

Abstract:

Disclosed are compounds of the formula: where R , R , R , R , R , R , and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.

US Patent:

20030069246, Apr 10, 2003

Filed:

Feb 25, 2002

Appl. No.:

10/083245

Inventors:

James Darrow - Wallingford CT, US
Stephane De Lombaert - Madison CT, US
Charles Blum - Westbrook CT, US
Jennifer Tran - Guilford CT, US
Mark Giangiordano - Branford CT, US
David Griffith - Old Saybrook CT, US
Philip Carpino - Groton CT, US

Assignee:

Neurogen Corporation - Branford CT

International Classification:

A61K031/53
A61K031/519
C07D487/02

US Classification:

514/245000, 514/259300, 544/180000, 544/281000

Abstract:

Disclosed are compounds of the formula: where R, R, R, R, R, R, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.