David D Griffith

US Patent:

6353062, Mar 5, 2002

Filed:

Feb 11, 2000

Appl. No.:

09/501700

Inventors:

Carl J. Giardino - Hixson TN
David B. Griffith - Houston TX
James M. Howell - Greenville NC
Michelle Hoyt Watkins - Waynesboro VA
Joseph James Duffy - Newark DE

Assignee:

E. I. du pont de Nemours and Company - Wilmington DE

International Classification:

C08F 200

US Classification:

526 65, 528272, 5283086, 526 67, 526 68, 526 71

Abstract:

A continuous process for the production of poly(trimethylene terephthalate) is disclosed. According to the process, a liquid feed mixture comprising bis-3-hydroxypropyl terephthalate and/or low molecular weight polyesters of 1,3-propanediol and terephthalic acid, the liquid feed mixture having a mole ratio of propylene groups to terephthalate groups of 1. 1 to 2. 2 is fed to a prepolymerizer. Bis-3-hydroxypropyl terephthalate and the low molecular weight polyesters are continuously polymerized to form a poly(trimethylene terephthalate) prepolymer and a first stream of gaseous by-products. Poly(trimethylene terephthalate) prepolymer having a relative viscosity of at least about 5 is continuously withdrawn from the prepolymerizer and continuously fed to a final polymerizer, where it is continuously polymerized to form a higher molecular weight poly(trimethylene terephthalate) and a second stream of gaseous by-products. Higher molecular weight poly(trimethylene terephthalate) having a relative viscosity of at least about 17 is continuously withdrawn from the final polymerizer.

US Patent:

6538076, Mar 25, 2003

Filed:

May 22, 2001

Appl. No.:

10/057497

Inventors:

Carl J. Giardino - Hixson TN
David B. Griffith - Houston TX
James M. Howell - Greenville NC
Michelle Hoyt Watkins - Waynesboro VA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C08F 200

US Classification:

526 65

Abstract:

A continuous process for the production of poly(trimethylene terephthalate) is disclosed. According to the process, a liquid feed mixture comprising bis-3-hydroxypropyl terephthalate and/or low molecular weight polyesters of 1,3-propanediol and terephthalic acid, the liquid feed mixture having a mole ratio of propylene groups to terephthalate groups of 1. 1 to 2. 2 is fed to a flasher. A first stream of gaseous by-products is continuously vaporized and removed from the flasher, and a liquid flasher reaction product having a mole ratio of propylene groups to terephthalate groups of less than about 1. 5 is continuously withdrawn from the flasher. The liquid flasher reaction product is continuously fed to a prepolymerizer where it is continuously polymerized to form a poly(trimethylene terephthalate) prepolymer and a second stream of gaseous by-products. Poly(trimethylene terephthalate) prepolymer having a relative viscosity of at least about 5 is continuously withdrawn from the prepolymerizer and continuously fed to a final polymerizer, where it is continuously polymerized to form a higher molecular weight poly(trimethylene terephthalate) and a third stream of gaseous by-products. Higher molecular weight poly(trimethylene terephthalate) having a relative viscosity of at least about 17 is continuously withdrawn from the final polymerizer.

US Patent:

6951954, Oct 4, 2005

Filed:

Feb 11, 2000

Appl. No.:

09/503599

Inventors:

Carl J. Giardino - Hixson TN, US
David B. Griffith - Houston TX, US
James M. Howell - Greenville NC, US
Michelle Hoyt Watkins - Waynesboro VA, US

Assignee:

E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

C07C067/02

US Classification:

560 92, 560 91, 562 89, 562 92, 562103

Abstract:

A process for the continuous production of at least one of bis(3-hydroxypropyl) terephthalate and low molecular weight oligomers of 1,3-propanediol and terephthalic acid is disclosed. According to the process, preheated 1,3-propanediol (about 150 C. to about 200 C. ) and preheated lower dialkyl esters of terephthalic acid (about 150 C. to about 220 C. ) are combined in a mole ratio of about 1. 2:1 to about 2. 3:1 and fed to an ester exchange vessel where the mixture undergoes a continuous transesterification reaction. The liquid reaction mixture is continuously heated and mixed, at a temperature of about 215 C. to about 250 C. , and a pressure of about 800 mm Hg to about 1,000 mm Hg. Gaseous reaction products are continuously separated from the liquid reaction mixture, and a stream of liquid reaction products containing bis(3-hydoxypropyl) terephthalate and low molecular weight oligomers of 1,3-propanediol and terephthalic acid is continuously removed from a base portion of the ester exchange vessel.

US Patent:

7132484, Nov 7, 2006

Filed:

Mar 29, 2005

Appl. No.:

11/093092

Inventors:

Carl J. Giardino - Hixson TN, US
David B. Griffith - Victoria TX, US
James M. Howell - Greenville NC, US
Michelle Hoyt Watkins - Fishersville VA, US

Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE

International Classification:

C08F 2/00

US Classification:

526 65, 526 66, 526 67, 526 71, 528274, 5283086, 528481, 528501, 528503, 428364, 428480

Abstract:

A continuous process for the production of poly(trimethylene terephthalate) is disclosed. According to the process, a liquid feed mixture comprising bis-3-hydroxypropyl terephthalate and/or low molecular weight polyesters of 1,3-propanediol and terephthalic acid, the liquid feed mixture having a mole ratio of propylene groups to terephthalate groups of 1. 1 to 2. 2 is fed to a flasher. A first stream of gaseous by-products is continuously vaporized and removed from the flasher, and a liquid flasher reaction product having a mole ratio of propylene groups to terephthalate groups of less than about 1. 5 is continuously withdrawn from the flasher. The liquid flasher reaction product is continuously fed to a prepolymerizer where it is continuously polymerized to form a poly(trimethylene terephthalate) prepolymer and a second stream of gaseous by-products. Poly(trimethylene terephthalate) prepolymer having a relative viscosity of at least about 5 is continuously withdrawn from the prepolymerizer and continuously fed to a final polymerizer, where it is continuously polymerized to form a higher molecular weight poly(trimethylene terephthalate) and a third stream of gaseous by-products. Higher molecular weight poly(trimethylene terephthalate) having a relative viscosity of at least about 17 is continuously withdrawn from the final polymerizer.

US Patent:

8507681, Aug 13, 2013

Filed:

Oct 4, 2012

Appl. No.:

13/644415

Inventors:

David Andrew Griffith - Sudbury MA, US
Daniel Wei-Shung Kung - Salem CT, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 401/04
C07D 401/14
A61K 31/438

US Classification:

546 17, 514278

Abstract:

The invention provides a compound of Formula (I).

US Patent:

20020132962, Sep 19, 2002

Filed:

Feb 7, 2002

Appl. No.:

10/080497

Inventors:

Carl Giardino - Hixson TN, US
David Griffith - Houston TX, US
James Howell - Greenville NC, US
Michelle Watkins - Waynesboro VA, US

International Classification:

C08G063/02

US Classification:

528/272000

Abstract:

A continuous process for the production of poly(trimethylene terephthalate) is disclosed. According to the process, a liquid feed mixture comprising bis-3-hydroxypropyl terephthalate and/or low molecular weight polyesters of 1,3-propanediol and terephthalic acid, the liquid feed mixture-having a mole ratio of propylene groups to terephthalate groups of 1.1 to 2.2 is fed to a flasher. A first stream of gaseous by-products is continuously vaporized and removed from the flasher, and a liquid flasher reaction product having a mole ratio of propylene groups to terephthalate groups of less than about 1.5 is continuously withdrawn from the flasher. The liquid flasher reaction product is continuously fed to a prepolymerizer where it is continuously polymerized to form a poly(trimethylene terephthalate) prepolymer and a second stream of gaseous by-products. Poly(trimethylene terephthalate) prepolymer having a relative viscosity of at least about 5 is continuously withdrawn from the prepolymerizer and continuously fed to a final polymerizer, where it is continuously polymerized to form a higher molecular weight poly(trimethylene terephthalate) and a third stream of gaseous by-products. Higher molecular weight poly(trimethylene terephthalate) having a relative viscosity of at least about 17 is continuously withdrawn from the final polymerizer.

US Patent:

20030220465, Nov 27, 2003

Filed:

Feb 25, 2003

Appl. No.:

10/373587

Inventors:

Carl Giardino - Hixson TN, US
David Griffith - Houston TX, US
James Howell - Greenville NC, US
Michelle Watkins - Waynesboro VA, US

International Classification:

C08G063/00
C08G069/00
C08G067/00
C08G063/02
C08G063/12

US Classification:

528/271000, 528/272000, 528/296000

Abstract:

A continuous process for the production of poly(trimethylene terephthalate) is disclosed. According to the process, a liquid feed mixture comprising bis-3-hydroxypropyl terephthalate and/or low molecular weight polyesters of 1,3-propanediol and terephthalic acid, the liquid feed mixture-having a mole ratio of propylene groups to terephthalate groups of 1.1 to 2.2 is fed to a flasher. A first stream of gaseous by-products is continuously vaporized and removed from the flasher, and a liquid flasher reaction product having a mole ratio of propylene groups to terephthalate groups of less than about 1.5 is continuously withdrawn from the flasher. The liquid flasher reaction product is continuously fed to a prepolymerizer where it is continuously polymerized to form a poly(trimethylene terephthalate) prepolymer and a second stream of gaseous by-products. Poly(trimethylene terephthalate) prepolymer having a relative viscosity of at least about 5 is continuously withdrawn from the prepolymerizer and continuously fed to a final polymerizer, where it is continuously polymerized to form a higher molecular weight poly(trimethylene terephthalate) and a third stream of gaseous by-products. Higher molecular weight poly(trimethylene terephthalate) having a relative viscosity of at least about 17 is continuously withdrawn from the final polymerizer.

US Patent:

20130296319, Nov 7, 2013

Filed:

Jul 11, 2013

Appl. No.:

13/939450

Inventors:

David Andrew Griffith - Sudbury MA, US
Daniel Wei-Shung Kung - Salem CT, US

International Classification:

C07D 471/10
C07D 519/00

US Classification:

5142345, 546 17, 514278, 544230, 514256, 514249, 5142593, 544 70, 544282, 5142591

Abstract:

The invention provides a compound of Formula (I)or a pharmaceutically acceptable salt of the compound, wherein R, R, Rand Rare as described herein; pharmaceutical compositions thereof and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

Address:

806 Hamlet St, Columbus, OH 43215

Phone:

6142994628

VIN:

WBXPC93457WF05229

Make:

BMW

Model:

X3 3.0SI

Year:

2007