David E Grove

US Patent:

20150140676, May 21, 2015

Filed:

Jan 13, 2015

Appl. No.:

14/595408

Inventors:

- Cleveland OH, US
Ibrahim Hanouneh - Cleveland Hts. OH, US
Nizar Zein - Highland Hts. OH, US
David Grove - Middleburg Hts. OH, US

International Classification:

G01N 33/497

US Classification:

436111

Abstract:

Various methods for determining whether a subject has alcoholic hepatitis are described. In one aspect, a method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis. In another aspect of the present invention a method for assessing a subject as having alcoholic hepatitis (AH) includes determining the level of trimethylamine and the level of pentane in a biological sample obtained from the subject. A TAP score is determined based on the concentration of trimethylamine and the concentration of pentane. The subject is diagnosed as having alcoholic hepatitis if the TAP score exceeds a control value.

US Patent:

20140093970, Apr 3, 2014

Filed:

Sep 30, 2013

Appl. No.:

14/041602

Inventors:

- CLEVELAND OH, US
Ibrahim Hanouneh - Cleveland Hts. OH, US
Nizar Zein - Highland Hts. OH, US
David Grove - Middleburg Hts. OH, US

Assignee:

THE CLEVELAND CLINIC FOUNDATION - CLEVELAND OH

International Classification:

G01N 33/497

US Classification:

436111

Abstract:

A method for determining whether a subject has alcoholic hepatitis is described. The method includes determining the levels of a trimethylamine in a biological sample obtained from the subject. The level of trimethylamine in the biological sample is compared to the control value, and the subject whose level of trimethylamine exceeds the control value is diagnosed as having alcoholic hepatitis.