David Henry Hackos

age ~56

from Burlingame, CA

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Also known as:

David H Hackos
Lauren F Cony
Brush I Tony

Phone and address:: 520 Howard Ave, Burlingame, CA 94010
4156249550

Connected to:

David Hackos Phones & Addresses

520 Howard Ave, Burlingame, CA 94010 • 4156249550
Evergreen, CO
834 Arkansas St, San Francisco, CA 94107
1222 Clayton St, San Francisco, CA 94114
San Mateo, CA
Rockville, MD
520 Howard Ave, Burlingame, CA 94010

Work

Company:

Genentech
Jun 2009
Address:

South San Francisco, CA
Position:

Scientist

Education

Degree:

PhD
School / High School:

University of California, San Francisco
1991 to 1998
Specialities:

Biophysics

Skills

Drug Discovery • Assay Development • R&D • Pharmacology • High Throughput Screening • Cell • Ion Channels • Pharmaceutical Industry • Neuroscience • Physiology • In Vitro • Electrophysiology • Biomarkers • Cell Culture • Cell Biology

Industries

Pharmaceuticals

Resumes

Scientist At Genentech

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Position:

Scientist at Genentech

Location:

San Francisco Bay Area

Industry:

Pharmaceuticals

Work:

Genentech - South San Francisco, CA since Jun 2009
Scientist
Roche Pharmaceuticals - Palo Alto, CA May 2007 - Jun 2009
Research Scientist II
Renovis - South San Francisco, CA 2001 - 2007
Senior Scientist
National Institutes of Health - Bethesda, MD 1998 - 2001
Postdoctoral Fellow

Education:

University of California, San Francisco 1991 - 1998
PhD, Biophysics The Johns Hopkins University 1987 - 1991
B.A., Physics

Skills:

Drug Discovery
Assay Development
R&D
Pharmacology
High Throughput Screening
Cell
Ion Channels
Pharmaceutical Industry
Neuroscience
Physiology
In Vitro
Electrophysiology
Biomarkers
Cell Culture
Cell Biology

Us Patents

Vr1 Receptors And Uses Thereof
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US Patent:

20050266435, Dec 1, 2005
Filed:

Mar 9, 2005
Appl. No.:

11/076431
Inventors:

David Hackos - San Francisco CA, US
Tito Serafini - San Mateo CA, US
Nina Orike - San Francisco CA, US
International Classification:

C12Q001/68
G01N033/53
G01N033/567
US Classification:

435006000, 435007200
Abstract:

The present invention relates to nucleic and amino acid sequences encoding vanilloid receptors which are vanilloid-insensitive. The present invention provides mutant vanilloid receptors which are insensitive to vanilloid, but which are capable of responding to low pH, heat and other receptor modulators. The invention particularly provides mutant vanilloid insensitive human VR1 receptors. The invention also relates to methods and assays for screening for vanilloid receptor modulators that act independent of the vanilloid binding site and modulate receptor signals independent of a functional vanilloid, or capsaicin, response. The invention further provides methods of modulating the vanilloid receptor, independent of vanilloid response.

Constituitively Open Voltage-Gated Kand Methods For Discovering Modulators Thereof
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US Patent:

20030211575, Nov 13, 2003
Filed:

Dec 27, 2002
Appl. No.:

10/203578
Inventors:

Kenton Swartz - Rockville MD, US
David Hackos - San Francisco CA, US
International Classification:

A01K067/00
C07H021/04
C12N001/18
C12P021/02
C12N005/06
C07K014/47
US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500, 800/008000, 435/254210
Abstract:

The present invention provides voltage-gated K channels with amino acid substitutions that produce a constitutively open phenotype when expressed in the cell. The invention includes mutated purified proteins with constitutively open voltage-gated K channel activity, for example those derived from Shaker, Shab, Shal, and Shaw family of voltage-gated K channels. The invention also includes nucleic acid encoding constitutively open voltage-gated K channels, as well as cells and transgenic animals expressing constitutively open voltage-gated K channels. Methods are provided for screening substances for ability to modulate voltage-gated K channels, by exploiting the ability of constitutively active voltage-gated K channels to affect growth or other phenotypic or genotypic characteristics in eukaryotic cells.