David E Heilman

US Patent:

7045552, May 16, 2006

Filed:

Sep 16, 2003

Appl. No.:

10/663589

Inventors:

David Heilman - Hillsborough NC, US
Jie Di - Chapel Hill NC, US
Brian Bray - Graham NC, US

Assignee:

Trimeris, Inc. - Morrisville NC

International Classification:

A61K 47/30

US Classification:

5147723, 5147721, 514773, 530300, 530324, 424 7807, 4241851, 4241861, 4241881

Abstract:

Provided is a pharmaceutical composition comprising a solution comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Also provided is a synthetic peptide-containing pharmaceutical composition as a unit dose comprising an aqueous formulation comprised of synthetic peptide in a final concentration of not less than 70 mg/ml in admixture with a polyol; wherein the synthetic peptide is an HIV fusion inhibitor, and wherein the polyol is in a final concentration of no less than 5 weight % and no more than 75 weight % of the pharmaceutical composition. Further provided is a method of treating HIV infection by administering to an HIV-infected individual a pharmaceutical composition according to the present invention.