David B Howland

US Patent:

7888486, Feb 15, 2011

Filed:

Aug 14, 2006

Appl. No.:

11/503062

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Wilmington DE

International Classification:

C07K 16/24
C07K 16/00
C07K 16/46

US Classification:

53038824, 5303871, 5303873, 5303881

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

7910107, Mar 22, 2011

Filed:

Jul 24, 2009

Appl. No.:

12/508618

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Erika L. F. Holzbaur-Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newton Square PA, US
Nicholas Weber - Mountaintop PA, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

WYETH LLC - Wilmington DE
The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241331

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

8349327, Jan 8, 2013

Filed:

Feb 18, 2011

Appl. No.:

13/030978

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

8372625, Feb 12, 2013

Filed:

Mar 2, 2011

Appl. No.:

13/038954

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US
William Kelley - Reading MA, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C07K 16/00
C12N 5/10
C12N 1/19
C12N 15/63
C12N 1/21
C07H 21/04
C12P 21/06

US Classification:

43525233, 43525231, 4352523, 4352542, 43525421, 43525422, 4353201, 435325, 435352, 435358, 435367, 435 696, 5303871, 536 2353

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

8496934, Jul 30, 2013

Filed:

Dec 4, 2012

Appl. No.:

13/693995

Inventors:

Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

55210864, May 28, 1996

Filed:

Sep 16, 1993

Appl. No.:

8/122889

Inventors:

Richard W. Scott - Wallingford PA
Russell A. Brierley - West Chester PA
David S. Howland - Exton PA

Assignee:

Cephalon, Inc. - West Chester PA

International Classification:

C12N 119
C12N 121
C12N 1562

US Classification:

4352542

Abstract:

The invention generally features a novel recombinant DNA molecule useful for producing a heterologous protein, e. g. , insulin-like growth factor-I, in yeast. The DNA molecule includes the following sequences joined in frame and in the following 5' to 3' progression: a sequence encoding a signal peptide of a yeast secreted protein; a sequence encoding at least 5 amino acids of the N-terminal region of a mature acid phosphatase protein, a sequence encoding a heterologous protein. Preferably the DNA molecule also encodes a spacer element that includes a proteolytic cleavage site.

US Patent:

20150152176, Jun 4, 2015

Filed:

Jan 22, 2015

Appl. No.:

14/603231

Inventors:

- Madison NJ, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

International Classification:

C07K 16/22
G01N 33/74
G01N 33/68

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

20140086920, Mar 27, 2014

Filed:

Jun 5, 2013

Appl. No.:

13/910834

Inventors:

- MADISON NJ, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

International Classification:

C07K 16/24

US Classification:

4241351, 4241391, 4241331

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.