David Frederik Fischer - Leiden, NL Richard Antonius Jozef Janssen - Leiden, NL Remko De Pril - Leiden, NL Desiré Maria Petronella Catharina Van Steenhoven - Leiden, NL Seung Kwak - Princeton NJ, US David S. Howland - Princeton NJ, US Ethan Signer - Princeton NJ, US
The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these
Target Sequences And Methods To Identify The Same, Useful In Treatment Of Neurodegenerative Diseases
David Frederik Fishcher - Leiden, NL Richard Antonius Janssen - Leiden, NL Remko De Pril - Leiden, NL Desiré Maria Petronella Catharina Van Steenhoven - Leiden, NL Seung Kwak - Princeton NJ, US David S. Howland - Princeton NJ, US Ethan Signer - Princeton NJ, US
514 44 A, 435 71, 506 9, 536 245, 536 231, 4353201, 435375, 514 44 R
Abstract:
The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETS.
Name / Title
Company / Classification
Phones & Addresses
David Howland Hoosic Housatonic Basin
National Guard, Massachusetts National Security
24 Beacon St, Boston, MA 02133
David Howland VP Finance
Industrial Metal Products Co., Inc Mfg Sheet Metalwork Structural Metal Fabrication · Sheet Metal Work Mfg · Sheet Metal Fabricators
15 Merchant St, Sharon, MA 02067 7815365132, 7817623330
Qlik
Senior Solutions Engineer
Google Oct 2016 - May 2017
Technical Analyst and Programmer
Pseg Jun 1, 2015 - Jul 2016
Application Developer
Application Security, Inc. Feb 2013 - Mar 2014
Manager, Technical Support
Fdr/Innovation Apr 2010 - Feb 2013
Technical Support Representative
Education:
Montclair State University 1999 - 2009
Computer School
Skills:
Data Warehousing Microsoft Sql Server Technical Support Sql Software Development Troubleshooting Customer Service Business Intelligence Cloud Computing Enterprise Software Windows Sdlc Databases Quality Assurance Linux Program Management Business Analysis Oracle Integration Enterprise Architecture Java Virtualization Security Software Project Management Requirements Analysis Disaster Recovery Hyper V Microsoft Office Analytics Agile Methodologies Sql Server Customer Relations
Interests:
Data Warehousing Technology Stock Chart Analysis Medicine Publishing Analytics (Business and Bio) Health
RAYMOND'S CORPORATION Greene, NY Sep 2013 to Nov 2013 forklift Transmission AssemblerCHOBANI INC New Berlin, NY Jul 2010 to Apr 2013 Machine Operator/ TrainerAMPHENOL AEROSPACE Sidney, NY Mar 2003 to Mar 2009 Molding machine operator/trainer
Education:
SUNY DELHI Delhi, NY Aug 1998 associates in applied science in Drafting and DesignSIDNEY CENTRAL SCHOOL New York, NY Jun 1996 High School Diploma in areas of studies related to Architectural designRobert W Harold campus Sidney Center, NY 1994 to 1996 2 year certification in Drafting and Design
David Howland Photographic Services Huntinton, WV 1992 to 2015 Owner/ProprietorMack Daves Huntington, WV Feb 1982 to 1999 Dept ManagerInternational Camera Exchange Boston, MA 1982 to Sep 1982 Store ManagerVail Associates Vail, CO 1981 to 1982 Vending ServicemanMack & Dave's Huntington, WV 1979 to 1982 Dept. Manager/buyer
Education:
Kaplan University 2006 Finance/Certified Insurance Sales WVNikon School of Photography Columbus, OH 1981 to 1981 Certificate of achievement in physics of light properties and filtrations.Marshall University 1977 to 1979 Liberal ArtsHuntington High School 1977 Art
Skills:
Self taught pro camera and lens repair utilizing micro tools like tweezers, screwdrivers, loupes, etc. Proficient with power tools. I'm a DIY'er around the house and am inclined to troubleshoot and repair before replacing.
Nov 2011 to Present DriverWal-mart Lynn, MA Nov 2009 to Mar 2010 AssociateTom's Taxi Lynn, MA Apr 2009 to Jun 2009 DriverDiapering Lynn, MA Jan 2007 to Nov 2008 Babysitter, Private personSunoco Gas Beverly, MA Jul 2008 to Oct 2008 CashierBeverly Taxi Beverly, MA Feb 2008 to Apr 2008 DriverSuper Stop n Shop Danvers, MA Jun 2006 to Dec 2006 Deli ClerkT.E. Anderson Salem, MA Feb 2006 to May 2006 LaborerJohnnies Food Master Lynn, MA Jan 2005 to Nov 2005 Deli & Seafood Clerk
Education:
Springfield Job Corp Sprinfield Jan 2004 to Jan 2006 Certificate in Welding
Skills:
Microsoft Office, Mig Welding, Tig Welding, Oxycetilyne Welding, Multiline Phones, Customer Service, Internet Search
Sep 2012 to 2000 Senior Small Business SpecialistRecreational Equipment Inc
Apr 2010 to 2000 Sales SpecialistBlueStar Business Services Group Lincoln, RI Sep 2009 to Sep 2012 Senior Sales ManagerJohn Deere Company Lunenburg, MA Feb 2009 to Jul 2009 General ManagerJohn Deere Company
Mar 1990 to Jul 2009John Deere Company Lincoln, RI Apr 2000 to Dec 2008 AG /C&CE Territory ManagerJohn Deere Company Raleigh, NC Jan 1998 to Jan 2000 Manager Customer SupportJohn Deere Company Raleigh, NC Apr 1995 to Jan 1998 AdvisorJohn Deere Company
Mar 1990 to Apr 1995
Education:
Boston University Boston, MA Mar 1993 to Sep 1994 Economics, ConcentratedPenn State University University Park, PA May 1989 Bachelor of Science in Economics
Montana State University - Bozeman - Economics, Cape Cod Academy
About:
Adventure photographer and student living in Bozeman, MT. I love taking pictures of anything adventurous - skiing, climbing, hiking, and biking. I'm majoring in Economics at Montana State Universi...
Montana State University - Peer Leader (2013) Frigid Light Company - Owner (2007) Big Sky Resort - Volunteer Ski Patrol (2010) Corner Cycle Cape Cod - Manager (2005)
Education:
Montana State University - Bozeman - Economics
David Howland
Education:
Ferris State University - Digital Animation and Game Design
Tagline:
3D Modeler, Animator, and Video Compositor in the Grand Rapids area.
David Howland
Tagline:
A youtube channel reviewing trade paperbacks and graphic novels from the perspective of someone new to comics. This channel is valuable to those of us new to comics, and people craving an organized and regular channel dedicated to comics and comics news. Remember, some may disagree with what I say. The fact is it's the humanity in all of us.