David B Howland

US Patent:

6787319, Sep 7, 2004

Filed:

May 9, 2001

Appl. No.:

09/852100

Inventors:

Bradley A. Ozenberger - Newtown PA
Jonathan A. Bard - Doylestown PA
Eileen M. Kajkowski - Ringoes NJ
Jack S. Jacobsen - Ramsey NJ
Stephen G. Walker - East Windsor NJ
Heidi Sofia - Walla Walla WA
David Howland - Yardley PA

Assignee:

American Home Products Corp. - Madison NJ

International Classification:

C07K 500

US Classification:

435 71, 530300, 530350

Abstract:

Novel proteins which bind human -amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.

US Patent:

7101973, Sep 5, 2006

Filed:

Jul 16, 2004

Appl. No.:

10/892379

Inventors:

Bradley A. Ozenberger - Newtown PA, US
Jonathan A. Bard - Doylestown PA, US
Eileen M. Kajkowski - Ringoes NJ, US
Jack S. Jacobsen - Ramsey NJ, US
Stephen G. Walker - East Windsor NJ, US
Heidi Sofia - Walla Walla WA, US
David Howland - Yardley PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07K 14/00
C07K 1/00

US Classification:

530350, 530300, 530324

Abstract:

Novel proteins which bind human β-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided. Transgenic animals and knockout animals are also provided.

US Patent:

7888486, Feb 15, 2011

Filed:

Aug 14, 2006

Appl. No.:

11/503062

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Wilmington DE

International Classification:

C07K 16/24
C07K 16/00
C07K 16/46

US Classification:

53038824, 5303871, 5303873, 5303881

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

7910107, Mar 22, 2011

Filed:

Jul 24, 2009

Appl. No.:

12/508618

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Erika L. F. Holzbaur-Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newton Square PA, US
Nicholas Weber - Mountaintop PA, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

WYETH LLC - Wilmington DE
The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241331

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

8349327, Jan 8, 2013

Filed:

Feb 18, 2011

Appl. No.:

13/030978

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley, legal representative - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

8372625, Feb 12, 2013

Filed:

Mar 2, 2011

Appl. No.:

13/038954

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US
William Kelley - Reading MA, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C07K 16/00
C12N 5/10
C12N 1/19
C12N 15/63
C12N 1/21
C07H 21/04
C12P 21/06

US Classification:

43525233, 43525231, 4352523, 4352542, 43525421, 43525422, 4353201, 435325, 435352, 435358, 435367, 435 696, 5303871, 536 2353

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

8496934, Jul 30, 2013

Filed:

Dec 4, 2012

Appl. No.:

13/693995

Inventors:

Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc. , in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

7262336, Aug 28, 2007

Filed:

Apr 24, 2001

Appl. No.:

10/258561

Inventors:

Kathleen Young - Newtown PA, US
David S. Howland - Yardley PA, US
Karen L. Marquis - Yardley PA, US
Mark Ian Cockett - Newtown PA, US

Assignee:

Wyeth - Madison NJ

International Classification:

G01N 33/00
A01K 67/027
C12N 15/00

US Classification:

800 14, 800 3, 800 21

Abstract:

A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.