David Whitney Jensen

US Patent:

20090221834, Sep 3, 2009

Filed:

Apr 20, 2007

Appl. No.:

12/226484

Inventors:

David R. Jensen - Harvest AL, US
John E. Sidenstick - Newport TN, US

International Classification:

C07D 271/06
C07D 231/38

US Classification:

548131, 5483717

Abstract:

The disclosed invention relates to a process for preparing 5-β-keto-1,2,4-oxadiazoles of formula (I), and conversion of 5-β-keto-1,2,4-oxadiazoles (I) into N-pyrazolyl amidoximes of the formula (II) through reaction with hydrazine. The process is defined by two steps. An amidoxime, which may be prepared in situ, is condensed with a β-keto ester to form a 5-β-keto-1,2,4-oxadiazole. The 5-β-keto-1,2,4-oxadiazole is subsequently reacted with hydrazine to furnish the desired N-pyrazolyl amidoxime. The disclosed invention provides several advantages over the current state of the art for the synthesis of N-pyrazolyl amidoximes, which require the condensation of a pyrzolylamine with an actived substrate and subsequent reaction with hydroxyl amine. N-pyrazolyl amidoximes are useful synthetic intermediates, especially for the preparation of photographic developing chemicals.

US Patent:

63070359, Oct 23, 2001

Filed:

Jan 20, 1999

Appl. No.:

9/230196

Inventors:

Frank J. Rauscher - Wayne PA
David E. Jensen - Philadelphia PA

Assignee:

The Wistar Institute of Anatomy and Biology - Philadelphia PA

International Classification:

C07H 2102
C12N 1500
C12N 120
C12P 2106

US Classification:

536 231

Abstract:

Nucleic acid and amino acid sequences of a BRCA1 associated protein, BAP-1, are provided. These sequences, the protein, and anti-BAP-1 antibodies are useful in therapeutics and diagnostics for cancers associated with loss of the 3p21 chromosomal region and/or inappropriate BAP-1 levels.

US Patent:

20150283257, Oct 8, 2015

Filed:

Mar 11, 2015

Appl. No.:

14/645347

Inventors:

- Macclesfield, GB
- San Francisco CA, US
Martin Hans Bohlin - Sodertalje, SE
Tesfai Sebhatu - Sodertalje, SE
Bo lngvar Ymen - Sodertalje, SE
Eric Thomas Healy - Madison AL, US
David Richard Jensen - Harvest AL, US
David Thomas Jonaitis - Brookston IN, US
Stephan Parent - West Lafayette IN, US

International Classification:

A61K 47/48
C07C 55/07
C07D 489/04

Abstract:

Naloxol-polyethylene glycol conjugates of the formula:are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.