David S Lederman

US Patent:

8513603, Aug 20, 2013

Filed:

May 12, 2011

Appl. No.:

13/068483

Inventors:

David Lederman - Morgantown WV, US
Sandeep Chandril - Dehradun, IN

Assignee:

West Virginia University - Morgantown WV

International Classification:

G21K 7/00
H01J 37/26

US Classification:

250310, 250305, 250306, 250307, 2504923, 700 90, 700109, 700110, 702 27, 702 28, 702127, 702134, 378 6, 378 44, 378 45

Abstract:

A method utilizing characteristic x-ray emission from a single thin film or multilayer thin film when an electron beam impinges at a grazing angle with respect to the surface of the sample to capture structural and physical properties of the layers such as layer thickness, interfacial roughness, and stoichiometry of the sample.

US Patent:

20080160638, Jul 3, 2008

Filed:

Dec 21, 2007

Appl. No.:

11/962229

Inventors:

David Lederman - Morgantown WV, US
Daniel Flynn - Morgantown WV, US
Peter Mico Gannett - Morgantown WV, US
Odille Cue Noriega Myers - Morgantown WV, US

International Classification:

G01N 33/553
B01J 19/00
B05D 1/36
G01N 33/00
B05D 7/24
G03F 7/00

US Classification:

436525, 422 681, 427402, 427414, 4274191, 427404, 430296, 436 94, 436 86

Abstract:

A microcantilever sensor for targeted analyte detection can generally comprise a microcantilever having a base and a beam, a metallic coating disposed substantially only on a first surface of a distal-most end of the beam, and a receptor compound immobilized to the metallic coating wherein the receptor compound can have substantially exclusive binding interaction with the analyte. The receptor compound can be a thiol-terminated bifunctional compound having a receptor site with specific binding affinity for the analyte, for example, an isolated Fab′ fragment. The metallic coating can be a noble metal and/or a semi-noble metal, such as a bilayer of chromium and gold. The metallic coating can be applied to the microcantilever surface by electron-beam lithography.