David S Lok

US Patent:

8025901, Sep 27, 2011

Filed:

Nov 10, 2009

Appl. No.:

12/615859

Inventors:

Weiyuan John Kao - Middleton WI, US
Jing Li - Madison MN, US
David Lok - Madison WI, US
Rathna Gundloori - Maharastra, IN

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61K 35/00
A61K 9/10
A61K 47/48
C08G 81/00
C08L 101/00
C08L 101/14

US Classification:

424484, 424486, 5147721, 514774, 435177, 523113, 530815, 530817

Abstract:

Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.

US Patent:

20030083389, May 1, 2003

Filed:

Apr 23, 2002

Appl. No.:

10/128198

Inventors:

Weiyun Kao - Middleton WI, US
Jing Li - Madison WI, US
David Lok - Madison WI, US

International Classification:

C09K003/00

US Classification:

516/098000

Abstract:

Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.

US Patent:

20050276858, Dec 15, 2005

Filed:

Mar 30, 2005

Appl. No.:

11/093531

Inventors:

Weiyuan Kao - Middleton WI, US
Jeffrey Phillips - Neenah WI, US
Jing Li - Blaine MN, US
David Lok - Madison WI, US
Rathna Gundloori - Maharastra, IN

International Classification:

A61K009/70
A61K009/14

US Classification:

424487000

Abstract:

Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.

US Patent:

20060100369, May 11, 2006

Filed:

Nov 14, 2005

Appl. No.:

11/273393

Inventors:

Weiyuan Kao - Middleton WI, US
Jing Li - Madison WI, US
David Lok - Madison WI, US
Rathna Gundloori - Maharastra, IN

International Classification:

A61K 47/48

US Classification:

525054100

Abstract:

Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.