David D Lynn

US Patent:

6376690, Apr 23, 2002

Filed:

Aug 30, 1999

Appl. No.:

09/386205

Inventors:

Robert H. Grubbs - Pasadena CA
Heather D. Maynard - Pasadena CA
David M. Lynn - Somerville MA

Assignee:

California Institute O Technology - Pasadena CA

International Classification:

C07F 1500

US Classification:

556 21, 556136

Abstract:

The present invention generally relates to the discovery that the solubility of metal complexes may be readily manipulated by the addition of one or more solubility-enhancing compounds. This manipulation of the solubilities allows for the preparation of suitable samples for precise quantitative analysis and for the facile purification of the desired products from the reaction mixture containing one or more metal complexes. In one embodiment of the invention, the relative solubilities between two solutions are manipulated so as cause the metal complex found in a first solution to transfer to a second solution that is generally immiscible with the first solution. The metal complex is thus separated from the reaction mixture which comprises the first solution by the removal of the second solution. In another embodiment, the solubility-enhancing compounds of the present invention is used to prepare samples containing metal complexes for precise quantitative analysis such as inductively coupled plasma mass spectroscopy.

US Patent:

6486279, Nov 26, 2002

Filed:

Jun 14, 2001

Appl. No.:

09/882776

Inventors:

David M. Lynn - Pasadena CA
Eric L. Dias - Chapel Hill NC
Robert H. Grubbs - South Pasadena CA
Bernard Mohr - Heidelberg, DE

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C08G 6106

US Classification:

526171, 526 92, 526135, 526145, 526146, 526259, 526268, 526281, 526283, 526308, 526309, 526335, 526336, 525269, 525289, 525290, 525297, 26433113, 26433115

Abstract:

Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-methasis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula A L X Ru CHRâ where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where Râ is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.

US Patent:

62848526, Sep 4, 2001

Filed:

Oct 29, 1998

Appl. No.:

9/183025

Inventors:

David M. Lynn - Pasadena CA
Eric L. Dias - Chapel Hill NC
Robert H. Grubbs - South Pasadena CA
Bernard Mohr - Heidelberg, DE

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C08G 6106
C07C 604

US Classification:

526171

Abstract:

Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-metathesis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula A. sub. x L. sub. y X. sub. z Ru. dbd. CHR' where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where R' is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.