- Cambridge MA, US David T. MacPherson - Cambridge MA, US Osama Suleiman - Cambridge MA, US Michael Williams - Cambridge MA, US David R. Witty - Cambridge MA, US Thierry Bonnaud - Cambridge MA, US Richard Edwards - Cambridge MA, US
International Classification:
C07D 487/10
Abstract:
The invention relates to a novel process for preparing Spiro derivatives, in particular 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one, and to novel intermediates for use in said process along with processes for preparing said intermediates.
The invention relates to Spiro derivatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.
- Cambridge MA, US David T. MacPherson - Cambridge MA, US Michael Williams - Cambridge MA, US David R. Witty - Cambridge MA, US Julian Northen - Cambridge MA, US Kalyan Vasudevan - Cambridge MA, US
International Classification:
C07D 487/10
Abstract:
The invention relates to novel salts of 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one, to compositions containing said salts and to the use of said salts in treating diseases and conditions mediated by modulation of voltage-gated sodium channels.
The invention relates to spiro derivatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said derivatives and processes for their preparation.
With or without RTW laws, states across the US have seen union membership declining in recent years as a share of total employment, according to tracking by economists Barry Hirsch, David Macpherson, and Wayne Vroman, who wrote an article,Estimates of Union Density by State.
Date: Mar 06, 2015
Category: U.S.
Source: Google
Union vote key, yet a challenge, to defeating Walker
emocratic tilt, a trend fueled in part by the growing public-sector character of the union movement. In 2000, 42% of union members in Wisconsin were in the public sector. By 2011, that had risen to 55%, according to Unionstats, an online database maintained by scholars Barry Hirsch and David Macpherson.
Clearly, the anti-Issue 2 forces appealed to more than just union households. Only 13.7 percent of Ohio workers are in unions as of 2010, down from 21.1 percent in 1990 and 37.2 percent in 1970, according to researchers David Macpherson and Barry Hirsch.
Mutchmor Public School Ottawa Morocco 1967-1969, Ottawa New School Ottawa Morocco 1969-1970, Crestwood Elementary School Edmonton Azores 1970-1972, Crestwood Middle School Edmonton Azores 1972-1975
Community:
Stu Guthrie, Pat Weidenhamer, Paula Marvin, Laurie Cote
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