David J Mccomsey

US Patent:

6365617, Apr 2, 2002

Filed:

Jun 26, 2000

Appl. No.:

09/603229

Inventors:

David F. McComsey - Warminster PA
William J. Hoekstra - Chapel Hill NC
Bruce E. Maryanoff - Forest Grove PA
Han-Cheng Zhang - Lansdale PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 31416

US Classification:

514403, 5462757, 5462771, 5483625, 548468

Abstract:

The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

US Patent:

6630451, Oct 7, 2003

Filed:

Jun 22, 2000

Appl. No.:

09/599826

Inventors:

Han-Cheng Zhang - Lansdale PA
Bruce E. Maryanoff - Forest Grove PA
David F. McComsey - Warminster PA
Kimberly B. White - North Wales PA

Assignee:

OrthoMcNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07K 506

US Classification:

514 19, 514385, 514386, 514387, 514393, 514394, 548300, 548305, 5462734

Abstract:

The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

US Patent:

6740657, May 25, 2004

Filed:

Jan 29, 2002

Appl. No.:

10/059707

Inventors:

Bruce E. Maryanoff - Forest Grove PA
Han-Cheng Zhang - Lansdale PA
David F. McComsey - Warminster PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3805

US Classification:

514267, 514 19, 544250

Abstract:

The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.

US Patent:

6747127, Jun 8, 2004

Filed:

May 5, 2000

Appl. No.:

09/565715

Inventors:

David F. McComsey - Warminster PA
Bruce E. Maryanoff - Forest Grove PA
Michael J. Hawkins - Ambler PA

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

C07K 508

US Classification:

530331, 514 18, 514 19

Abstract:

The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

US Patent:

6849643, Feb 1, 2005

Filed:

Dec 6, 2001

Appl. No.:

10/013181

Inventors:

Han-Cheng Zhang - Lansdale PA, US
Bruce Maryanoff - Forest Grove PA, US
Bruce Conway - Doylestown PA, US
Kimberly White - North Wales PA, US
Hong Ye - Lansdale PA, US
Leonard Robert Hecker - Harleysville PA, US
David F. McComsey - Warminster PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Skillman NJ

International Classification:

A61K 314439
A61K 314709
A61K 314725
C07D40114

US Classification:

514307, 514314, 514339, 546139, 546152, 5462757

Abstract:

The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

US Patent:

6943149, Sep 13, 2005

Filed:

Mar 17, 2003

Appl. No.:

10/390098

Inventors:

Han-Cheng Zhang - Lansdale PA, US
Bruce E. Maryanoff - Forest Grove PA, US
David F. McComsey - Warminster PA, US
Kimberly B. White - North Wales PA, US

Assignee:

Ortho McNeil Pharmaceutical, Inc. - Raritan NJ
Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07K005/06

US Classification:

514 19, 514385, 514386, 514387, 514393, 514394, 548300, 548305, 5462734

Abstract:

The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

US Patent:

7125878, Oct 24, 2006

Filed:

May 6, 2003

Appl. No.:

10/430000

Inventors:

Han-Cheng Zhang - Lansdale PA, US
Bruce E. Maryanoff - Forest Grove PA, US
Hong Ye - Lansdale PA, US
David O'Neill - Flemington NJ, US
Lan Shen - Clinton NJ, US
Keith Demarest - Flemington NJ, US
Bruce R. Conway - Doylestown PA, US
David F. McComsey - Warminster PA, US

Assignee:

Janssen Pharmaceutica - Beerse

International Classification:

A61K 31/495
C07D 241/02
C07D 403/04

US Classification:

51425505, 544242, 544336, 544410, 546152, 5462681, 5462764, 5142521

Abstract:

The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

US Patent:

7232906, Jun 19, 2007

Filed:

Jun 4, 2003

Appl. No.:

10/454561

Inventors:

Han Cheng Zhang - Lansdale PA, US
Bruce E. Maryanoff - Forest Grove PA, US
David F. McComsey - Warminster PA, US
Kimberly White - North Wales PA, US
Hong Ye - Lansdale PA, US
Leonard R. Hecker - Harleysville PA, US
Bruce Conway - Doylestown PA, US
Keith Demarest - Flemington NJ, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07D 239/24
C07D 209/02

US Classification:

544333, 546144, 546167, 548455, 548465

Abstract:

The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.