David R Mcpherson

US Patent:

58583998, Jan 12, 1999

Filed:

Jun 6, 1996

Appl. No.:

8/659596

Inventors:

Gregory M. Lanza - Creve Coeur MO
Melvin E. Klegerman - Silver Spring MD
David D. McPherson - Chicago IL
Bonnie J. Kane - Elmhurst IL
Sasha E. Murer - Chicago IL

Assignee:

Northwestern University - Evanston IL

International Classification:

A61K 9127

US Classification:

424450

Abstract:

This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.

US Patent:

59579501, Sep 28, 1999

Filed:

Jun 13, 1997

Appl. No.:

8/874880

Inventors:

Lyle F. Mockros - Glenview IL
John M. Fildes - Batavia IL
Krishnan B. Chandran - Iowa City IA
Michael J. Vonesh - Flagstaff AZ
David D. McPherson - Chicago IL
Ashwin Nagaraj - Evanston IL
Charles Davidson - Winnetka IL

Assignee:

Northwestern University Medical School - Chicago IL

International Classification:

A61M 2510

US Classification:

606194

Abstract:

A system and method for performing balloon angioplasty treatment on a patient. The system includes a catheter for insertion into an artery of the patient, a balloon coupled to the catheter with the balloon expandable by fluid passed through the catheter in order to apply pressure to plaque lesions deposited on vascular tissue of the artery. The balloon includes a PVDF piezoelectric transducer for sensing acoustic emission signals generated by deformation of the plaque lesions and the vascular tissue. The acoustic emission signals can be analyzed by frequency analysis, time domain analysis and wavelet analysis followed by neural net correlation evaluation.

US Patent:

56120575, Mar 18, 1997

Filed:

Oct 11, 1995

Appl. No.:

8/541185

Inventors:

Gregory M. Lanza - Evanston IL
M. Hayat Onyuksel - LaGrange IL
Melvin E. Klegerman - Chicago IL
Michael J. Vonesh - Northbrook IL
David L. McPherson - Chicago IL

Assignee:

Northwestern University - Evanston IL

International Classification:

A61K 9127

US Classification:

424450

Abstract:

This invention relates to tissue specific acoustically reflective oligolamellar liposomes containing internally separated bilayers and methods to make and to use the same, alone as a perfusion ultrasonic contrast agent or conjugated to a ligand for tissue-specific ultrasonic image enhancement.