David M Meyers

US Patent:

8476458, Jul 2, 2013

Filed:

Jun 19, 2008

Appl. No.:

12/665751

Inventors:

Ronen Marmorstein - Swarthmore PA, US
Xin Liu - Menlo Park CA, US
Philip A. Cole - Baltimore MD, US
Ling Wang - Seattle WA, US
Erin M. Bowers - Baltimore MD, US
David J. Meyers - Towson MD, US
Chandrani Mukherjee - Baltimore MD, US

Assignee:

The Wistar Institute - Philadelphia PA
The John Hopkins University - Baltimore MD

International Classification:

C07D 231/00
C07D 231/06
C07D 307/00
C07D 317/00
C07D 323/02

US Classification:

5483657, 5483561, 5483661, 5483791, 549429

Abstract:

The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.

US Patent:

51218046, Jun 16, 1992

Filed:

Mar 12, 1991

Appl. No.:

7/668227

Inventors:

David A. Labs - Telford PA
David M. Meyers - Emmaus PA

International Classification:

G01G 1960

US Classification:

177132

Abstract:

A fishing pole is provided wherein the handle is defined as a scale, with a hook projecting coaxially and exteriorly of the handle at a rear terminal end thereof for mounting and weighing of a fish thereon. A further embodiment of the invention for use in bait casting organizations mounts a scale in parallel contiguous relationship relative to the handle, with the hook directed orthogonally relative to the housing of the scale for weighing of fish subsequent to their catching.