David A Mott

US Patent:

8132443, Mar 13, 2012

Filed:

May 1, 2009

Appl. No.:

12/434180

Inventors:

R Andrew McGill - Lorton VA, US
Rekha Pai - Alexandria VA, US
David R. Mott - Burke VA, US
Jennifer L Stepnowski - Alexandria VA, US
Viet Nguyen - Gaithersburg MD, US

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

B01D 53/02

US Classification:

73 2339, 73 2342, 96101

Abstract:

The present invention is generally directed to a microfabricated gas chromatograph column having two patterned substrates, each optionally having a stationary phase material coating, bonded together to provide a continuous flow channel. The flow channel can have a serpentine arrangement or a modified serpentine arrangement comprising alternating series of consecutive turns in one direction where each series has enough turns to move carrier gas and analyte molecules from the center of the column cross section to an outer wall of the channel or from one outer wall of the channel to the opposite outer wall. Different portions of the substrates can be coated with differing thicknesses of stationary phase material and/or with different stationary phase materials. The column can have a circular cross-section or a semi-circular cross-section where the flat portion of the cross-section has grooves. Also disclosed is the related method of making the microfabricated gas chromatograph column.

US Patent:

8361413, Jan 29, 2013

Filed:

Jun 9, 2006

Appl. No.:

11/423225

Inventors:

David Mott - Burke VA, US
Frances S Ligler - Potomac MD, US
Stephanie Fertig - Springfield VA, US
Aron Bobrowski - Miami FL, US

Assignee:

The United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

B01L 3/00

US Classification:

422503, 422500, 422501, 422502, 422504

Abstract:

A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols.

US Patent:

8577658, Nov 5, 2013

Filed:

Mar 5, 2007

Appl. No.:

11/682068

Inventors:

David Mott - Burke VA, US
Joel P. Golden - Fort Washington MD, US

Assignee:

The United States of America as repesented by the Secretary of the Navy - Washington DC

International Classification:

G06G 7/50
G06G 7/48
G06F 7/60
G06F 17/10

US Classification:

703 9, 703 2

Abstract:

A computational “toolbox” can be used for the a priori design of optimized fluidic components. These components include a channel under low-Reynolds number, pressure-driven flow, with an arrangement of grooves cut into the top and/or bottom to generate a tailored cross-channel flow. An advection map for each feature (i. e. , groove of a particular shape and orientation) predicts the lateral transport of fluid within the channel due to that feature. Applying the advection maps in sequence generates a representation of the outflow distribution for complex designs that combine one or more features. Therefore, the effect of the complex three-dimensional flow field can be predicted without solving the governing flow equations through the composite geometry, and the resulting distribution of fluids in the channel is used to evaluate how well a component performs a specified task. The toolbox is applied to determine optimal combinations of features for specified mixer sizes and mixing metrics.

US Patent:

20120052521, Mar 1, 2012

Filed:

Jan 10, 2011

Appl. No.:

12/987251

Inventors:

David Mott - Burke VA, US
Frances S. Ligler - Potomac MD, US
Stephanie Fertig - Springfield VA, US
Aron Bobrowski - Miami FL, US

Assignee:

The Government of the United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

C12Q 1/02
F15D 1/00
B23P 17/00
C12M 1/34

US Classification:

435 29, 4352887, 137 1, 29592

Abstract:

A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols.

US Patent:

20140017149, Jan 16, 2014

Filed:

Dec 27, 2012

Appl. No.:

13/728651

Inventors:

David R. Mott - Burke VA, US
Frances S. Ligler - Potomac MD, US
Stephanie Fertig - Springfield VA, US
Aron Bobrowski - Miami FL, US

International Classification:

B01L 3/00

US Classification:

422502, 4251311

Abstract:

A sheath flow system having a channel with first and second fluid transporting structures located on opposing surfaces facing one another across the channel in the top and bottom surfaces of the channel situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols

US Patent:

20150343691, Dec 3, 2015

Filed:

Aug 12, 2015

Appl. No.:

14/824635

Inventors:

David R. Mott - Burke VA, US
Frances S. Ligler - Fuquay Varina NC, US
Stephanie Fertig - Springfield VA, US
Aron Bobrowski - Miami FL, US

Assignee:

The Government of the United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

B29C 47/30
B29C 47/08
B29C 47/00
B29C 47/06

Abstract:

A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.

US Patent:

20150266226, Sep 24, 2015

Filed:

May 29, 2015

Appl. No.:

14/725769

Inventors:

David R. Mott - Burke VA, US
Frances S. Ligler - Fuquay Varina NC, US
Stephanie Fertig - Springfield VA, US
Aron Bobrowski - Miami FL, US

Assignee:

The Government of the United States of America, as represented by the Secretary of the Navy - Washington DC

International Classification:

B29C 47/06

Abstract:

A sheath flow system having a channel with at least one fluid transporting structure located in the top and bottom surfaces situated so as to transport the sheath fluid laterally across the channel to provide sheath fluid fully surrounding the core solution. At the point of introduction into the channel, the sheath fluid and core solutions flow side by side within the channel or the core solution may be bounded on either side by the sheath fluid. The system is functional over a broad channel size range and with liquids of high or low viscosity. The design can be readily incorporated into microfluidic chips without the need for special manufacturing protocols. Uses include extruding materials and/or fabricating structures.

US Patent:

20140087466, Mar 27, 2014

Filed:

Mar 4, 2013

Appl. No.:

13/784216

Inventors:

Frances S. Ligler - Potomac MD, US
André A. Adams - Burke VA, US
Michael Daniele - Arlington VA, US
David R. Mott - Burke VA, US
Stephanie Fertig - Springfield VA, US
Aron Bobrowski - Miami FL, US

International Classification:

C12N 5/071
B29D 99/00

US Classification:

435400, 264 7

Abstract:

A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.