David G Pierce

US Patent:

6998489, Feb 14, 2006

Filed:

Nov 26, 2003

Appl. No.:

10/723297

Inventors:

Raymond E. Conrow - Crowley TX, US
Pete Delgado - Fort Worth TX, US
William D. Dean - Arlington TX, US
David R. Pierce - Fort Worth TX, US
Michael S. Gaines - Fort Worth TX, US

Assignee:

Alcon, Inc. - Hünenberg

International Classification:

C07D 231/56

US Classification:

5483625

Abstract:

Methods of making indazoles are described. The methods involved reacting an aromatic aldehyde with a nitrogen source to form a nitroso aromatic aldehyde. The nitroso aromatic aldehyde is reacted with a reducing agent to form an indazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.

US Patent:

20130289653, Oct 31, 2013

Filed:

Jul 3, 2013

Appl. No.:

13/934893

Inventors:

David Michael PIERCE - Plano TX, US

International Classification:

A61N 1/36

US Classification:

607 55

Abstract:

A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

US Patent:

20230040112, Feb 9, 2023

Filed:

Oct 18, 2022

Appl. No.:

17/968021

Inventors:

- Austin TX, US
Navzer ENGINEER - Plano TX, US
David PIERCE - Plano TX, US

International Classification:

A61F 11/00
A61B 5/12
A61N 1/36
A61N 1/372
G09B 23/28
H04R 25/00

Abstract:

A method (of treating a patient who has tinnitus) includes: providing to the patient a series of tones including at least a single tone which is at least a half-octave outside a tinnitus frequency of the patient; and applying vagus nerve stimulation to the patient to induce a period of plasticity in a cortex of the patient that is transitory and that represents a transitory opportunity for learning to occur; and wherein the at least a single tone occurs during the transitory opportunity for learning.

US Patent:

20170143550, May 25, 2017

Filed:

Feb 2, 2017

Appl. No.:

15/422958

Inventors:

- Austin TX, US
Navzer ENGINEER - Plano TX, US
David Michael PIERCE - Plano TX, US

International Classification:

A61F 11/00
H04R 25/00
A61B 5/12
A61N 1/36
A61N 1/372

Abstract:

A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

US Patent:

20170100590, Apr 13, 2017

Filed:

Dec 19, 2016

Appl. No.:

15/382970

Inventors:

- Austin TX, US
Nazer ENGINEER - Plano TX, US
David Michael PIERCE - Plano TX, US
Robert L. RENNAKER - Sachse TX, US

International Classification:

A61N 1/36
A61N 1/372
A61N 7/00
A61N 2/00

Abstract:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

US Patent:

20150094785, Apr 2, 2015

Filed:

Dec 4, 2014

Appl. No.:

14/560735

Inventors:

- Austin TX, US
David Michael PIERCE - Plano TX, US
Robert L. RENNAKER - Sachse TX, US

International Classification:

A61N 1/36
A61N 1/372

US Classification:

607 48

Abstract:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

US Patent:

20150073492, Mar 12, 2015

Filed:

Nov 21, 2014

Appl. No.:

14/550286

Inventors:

- Austin TX, US
David Michael PIERCE - Plano TX, US
Robert L. RENNAKER - Sachse TX, US

International Classification:

A61N 1/36

US Classification:

607 3

Abstract:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

US Patent:

20150073493, Mar 12, 2015

Filed:

Nov 21, 2014

Appl. No.:

14/550357

Inventors:

- Austin TX, US
David Michael PIERCE - Plano TX, US
Robert L. RENNAKER - Sachse TX, US

International Classification:

A61N 1/36

US Classification:

607 3

Abstract:

A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

Address:

411 Eastcliff Dr, Euless, TX 76040

VIN:

1G6DF577990162855

Make:

CADILLAC

Model:

CTS

Year:

2009

Address:

605 Marswen Dr, Nashville, TN 37216

Phone:

4789519642

VIN:

1GTEC19J08Z314530

Make:

GMC

Model:

SIERRA 1500

Year:

2008

Address:

1806B 7 Ave N, Nashville, TN 37208

VIN:

JTEBU11F770027076

Make:

TOYO

Model:

BU11

Year:

2007