David B Repke

US Patent:

6667301, Dec 23, 2003

Filed:

May 22, 2001

Appl. No.:

09/862286

Inventors:

Charles Alois Dvorak - Palo Alto CA
Lawrence Emerson Fisher - Mountain View CA
Keena Lynn Green - Newark CA
Hans Maag - Menlo Park CA
Anthony Prince - Los Altos CA
David Bruce Repke - Milpitas CA
Russell Stephen Stabler - Mountain View CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D24108

US Classification:

51421103, 51421203, 514218, 540488, 540492, 540531

Abstract:

This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR , and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

US Patent:

6787535, Sep 7, 2004

Filed:

Jun 6, 2002

Appl. No.:

10/164660

Inventors:

Colin Charles Beard - Palo Alto CA
Robin Douglas Clark - Palo Alto CA
Lawrence Emerson Fisher - Mountain View CA
David Bruce Repke - Milpitas CA
David George Putman - Saratoga CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 3133

US Classification:

514183, 51425409, 514415, 544366, 544358, 544373, 548452, 548469, 548511, 548503

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R , R or R is a group of general Formula B, wherein W is a âCHâ group or a nitrogen atom, and the other substituents are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

6790848, Sep 14, 2004

Filed:

Jun 14, 2002

Appl. No.:

10/172360

Inventors:

Andrew John Briggs - Mountain View CA
Robin Douglas Clark - Palo Alto CA
David Bruce Repke - Milpitas CA
Douglas Leslie Wren - Palo Alto CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D40304

US Classification:

51425409, 544373

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R is SO âAr, Ar is aryl or heteroaryl; and R , R , R and R are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

6943169, Sep 13, 2005

Filed:

Mar 10, 2004

Appl. No.:

10/797545

Inventors:

David Bruce Repke - Milpitas CA, US
Russell Stephen Stabler - Boulder Creek CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K031/497
C07D403/10

US Classification:

51425213, 51421207, 514312, 540523, 544363, 546157, 546158

Abstract:

The invention provides compounds of the formula: and pharmaceutically acceptable salts or prodrugs thereof, wherein m, p, q, r, A, E, X, Y, R, R, R, R, R, R, Rand are as defined herein. The invention also provides methods for preparing, compositions comprising, and methods for using compounds of formula I.

US Patent:

7022708, Apr 4, 2006

Filed:

Oct 16, 2003

Appl. No.:

10/687091

Inventors:

Robin Douglas Clark - Lawai HI, US
David Bruce Repke - Milpitas CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

C07D 403/04
A61K 31/496

US Classification:

51425409, 544373

Abstract:

This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein R, R, R, R, and Rare as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

7094778, Aug 22, 2006

Filed:

Oct 14, 2003

Appl. No.:

10/685124

Inventors:

Charles Alois Dvorak - Palo Alto CA, US
Lawrence Emerson Fisher - Mountain View CA, US
Keena Lynn Green - Newark CA, US
Hans Maag - Menlo Park CA, US
Anthony Prince - Los Altos CA, US
David Bruce Repke - Milpitas CA, US
Russell Stephen Stabler - Mountain View CA, US

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 31/513
C07D 279/06
C07D 413/12
C07D 239/10
C07D 241/08

US Classification:

5142272, 5142288, 5142358, 5142531, 51425402, 51425502, 514274, 544 54, 544 97, 544121, 544316, 544360, 544366, 544383

Abstract:

This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I:.

US Patent:

7229984, Jun 12, 2007

Filed:

Dec 9, 2005

Appl. No.:

11/298245

Inventors:

James M. Kress - Sanford NC, US
David Bruce Repke - Milpitas CA, US
Russell Stephen Stabler - Boulder Creek CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

C07D 267/02
C07D 281/02
C07D 243/10
C07D 498/00
A61K 31/55

US Classification:

51421104, 51421111, 514220, 540488, 540495, 540547

Abstract:

Compounds of the Formula I:.

US Patent:

7307089, Dec 11, 2007

Filed:

Jul 25, 2006

Appl. No.:

11/493461

Inventors:

James M. Kress - Raleigh NC, US
David Bruce Repke - Milpitas CA, US
Russell Stephen Stabler - Boulder Creek CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K 31/496
C07D 215/40

US Classification:

514312, 514318, 544363, 546153

Abstract:

Compounds of Formula 1.