David Rivera

US Patent:

57832137, Jul 21, 1998

Filed:

Mar 6, 1997

Appl. No.:

8/811812

Inventors:

David L. Rivera - San Jose CA
Sonya Merrill - Redwood City CA
James B. Eckenhoff - Los Altos CA
Jeremy C. Wright - Los Altos CA
James L. Osborne - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61K 924

US Classification:

424473

Abstract:

The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228. degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228. degree. C.

US Patent:

56098855, Mar 11, 1997

Filed:

Feb 10, 1995

Appl. No.:

8/387967

Inventors:

David L. Rivera - San Jose CA
Sonya Merrill - Redwood City CA
James B. Eckenhoff - Los Altos CA
Jeremy C. Wright - Los Altos CA
James L. Osborne - Mountain View CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61K 924

US Classification:

424473

Abstract:

The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228. degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228. degree. C.

US Patent:

54434610, Aug 22, 1995

Filed:

Aug 31, 1993

Appl. No.:

8/114800

Inventors:

Linda E. Atkinson - Portola Valley CA
John T. Dunn - Palo Alto CA
Robert M. Gale - Los Altos CA
David L. Rivera - San Jose CA

Assignee:

ALZA Corporation - Palo Alto CA

International Classification:

A61K 922

US Classification:

6048921

Abstract:

Diffusional delivery devices are constructed in two or more compartments, each containing a separate drug or other beneficial agent, and each arranged to permit diffusion of the agent out of the device through an individually-characterized agent-permeable wall segment. The diffusion rates of the various agents relative to one another are set and controlled by the parameters of the individual wall segments, such as the surface area of the wall segment, the average thickness of the wall segment, and the permeability of the wall segment for the particular agent. The permeability may be varied by variations in the chemical composition of the wall segment. Using these parameters rather than blending the agents at calculated ratios in a single formulation for diffusion through a single wall permits a wider range of, and greater flexibility in, variation between the diffusion rates of the different agents. This is of value when the simultaneous administration of agents at a specified ratio is desired.

US Patent:

56076967, Mar 4, 1997

Filed:

May 16, 1995

Appl. No.:

8/441888

Inventors:

David L. Rivera - San Jose CA
Sonya Merrill - Redwood City CA
James B. Eckenhoff - Los Altos CA
Jeremy C. Wright - Los Altos CA
James L. Osborne - Mountain View CA

Assignee:

Alza Corporation - Palo Alto CA

International Classification:

A61K 924

US Classification:

424473

Abstract:

The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228. degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228. degree. C.