David Joseph Robbins

US Patent:

7022472, Apr 4, 2006

Filed:

Oct 22, 1999

Appl. No.:

09/426548

Inventors:

David Robbins - Stevenson Ranch CA, US
Juili Lillian Lin-Goerke - Spring City PA, US
Jessica C. Ling - Bensalem PA, US

Assignee:

diaDexus, Inc. - So. San Francisco CA

International Classification:

C07H 21/02
C07H 21/04
C12Q 1/68

US Classification:

435 6, 536 231, 536 243

Abstract:

Variant human MLH1 and MSH2 genes are provided. Methods of using these variant genes to diagnose hereditary non-polyposis colorectal cancer (HNPCC) and/or determine a patient's susceptibility to developing HNPCC are also provided. Methods and compositions for identifying new variant MLH1 of MSH2 genes are also provided. In addition, experimental models for hereditary non-polyposis colorectal cancer comprising these variant genes are provided.

US Patent:

8273701, Sep 25, 2012

Filed:

Aug 14, 2006

Appl. No.:

12/063781

Inventors:

David J. Robbins - Hanover NH, US
Ziqiang Yuan - Burlington VT, US
John A. Goetz - Bloomington IN, US

Assignee:

Trustees of Dartmouth College - Hanover NH

International Classification:

A01N 61/00

US Classification:

514 1

Abstract:

The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.

US Patent:

20060121548, Jun 8, 2006

Filed:

Nov 8, 2005

Appl. No.:

11/270194

Inventors:

David Robbins - Stevenson Ranch CA, US
Charles Hwang - San Francisco CA, US

Assignee:

Remote Clinical Solutions, Inc. - San Francisco CA

International Classification:

C12Q 1/34
A61M 35/00
C12M 1/34

US Classification:

435018000, 435287100, 604001000

Abstract:

Systems and methods for measuring saliva sodium concentration using a chromatographic reaction enable rapid-results, low-cost diagnosis of various medical conditions in an outpatient setting. In one embodiment, measured patient saliva sodium concentration is used by the patient or the patient's healthcare provider to guide medical decision making. In another embodiment, measured patient saliva sodium concentration is processed to mechanically adjust the concentration of sodium in an aqueous solution to be delivered to the patient for oral administration. In yet another embodiment, a closed loop system measures saliva sodium concentration and uses any of a number of different types of feedback control systems to monitor and control the fluid and/or electrolyte state of the patient.

US Patent:

20060196082, Sep 7, 2006

Filed:

Feb 28, 2006

Appl. No.:

11/364567

Inventors:

David Robbins - Bethesda MD, US

International Classification:

A43C 13/00
A43B 13/28
A43B 21/36

US Classification:

036042000, 036024500, 036015000

Abstract:

The present invention relates to a removable modular heel assembly that is attached to a high heel shoe, which shoe may be adapted to accept the assembly, and which assembly is designed to increase the surface area of the heel or shoe to enhance stability, comfort, and/or balance for the wearer.

US Patent:

20070015287, Jan 18, 2007

Filed:

Jul 13, 2006

Appl. No.:

11/457408

Inventors:

David Robbins - Stevenson Ranch CA, US
Charles Hwang - Ridgewood NJ, US
Rebecca Eaton - San Francisco CA, US

Assignee:

Remote Clinical Solutions, Inc. - San Francisco CA

International Classification:

G01N 31/22

US Classification:

436164000

Abstract:

Methods and devices for measuring analyte concentration in a nonblood body fluid sample enable rapid-results, low-cost diagnosis of various medical conditions in an outpatient setting. In one embodiment, measured patient sodium concentration is used by the patient or the patient's healthcare provider to guide medical decision-making. In another embodiment, measured patient sodium concentration is processed to mechanically adjust the concentration of sodium in an aqueous solution to be delivered to the patient for oral administration. In yet another embodiment, a closed loop system measures saliva sodium concentration and uses any of a number of different types of feedback control systems to monitor and control the fluid and/or electrolyte state of the patient.

US Patent:

20080008768, Jan 10, 2008

Filed:

Nov 9, 2005

Appl. No.:

11/718752

Inventors:

David Robbins - Hanover NH, US
Ziqiang Yuan - Burlington VT, US
John Goetz - Bloomington IN, US
William Scott - Cincinnati OH, US
Sheila Bell - Cincinnati OH, US
Claire Schreiner - Cincinnati OH, US

International Classification:

A61K 33/24
A61P 35/00
G01N 33/53

US Classification:

424654000, 435007100

Abstract:

The present invention relates to the use of sonic hedgehog antagonists in the prevention and treatment of cancer and other hyperproliferative diseases or disorders. Methods for identifying such antagonists are also provided.

US Patent:

60870753, Jul 11, 2000

Filed:

Nov 7, 1997

Appl. No.:

8/966473

Inventors:

Edward J. Kler - Lakewood CA
David W. Robbins - Oxford CT
Robert R. Carey - Radnor PA

Assignee:

Label Systems, Inc. - Bridgeport CT

International Classification:

B42D 1500
B32B 706

US Classification:

430321

Abstract:

A tamper-evident label includes two parts that are separated from each other when an article to which they are attached is opened. The two parts have matching surface relief patterns secured to each other at an interface, and the indexes of refraction of the parts are substantially equal such that the patterns have no optical effect when attached to each other. When the two parts are separated, however, the patterns generate an image drawing attention to their separation. The patterns are preferably holographic.