David M Rubin

US Patent:

6541220, Apr 1, 2003

Filed:

Nov 30, 1999

Appl. No.:

09/449632

Inventors:

David A. Rubin - Needham MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 1512

US Classification:

435 691, 536 235, 536 243, 536 2431, 530350, 435 711, 435 712, 435471, 435325, 4353201, 4352523, 43525411

Abstract:

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

US Patent:

7078487, Jul 18, 2006

Filed:

Feb 25, 2003

Appl. No.:

10/372095

Inventors:

Harald Jüppner - Cambridge MA, US
David A Rubin - Needham MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C07K 14/72
C07K 14/435

US Classification:

530350, 530399

Abstract:

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

US Patent:

20060228353, Oct 12, 2006

Filed:

May 25, 2006

Appl. No.:

11/440090

Inventors:

David Rubin - Needham MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61K 39/395
C07H 21/04
C12P 21/06
C07K 16/28
C07K 14/72

US Classification:

424143100, 435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

US Patent:

20220383259, Dec 1, 2022

Filed:

May 26, 2022

Appl. No.:

17/826025

Inventors:

- Seattle WA, US
Robert Porcarelli - Seattle WA, US
Robert Paul Platzer - Saugerties NY, US
Kathlyn Bardaro - Snoqualmie WA, US
Zev Eigen - Amsterdam, NL
Olya Evanitsky - New York NY, US
Courtney Alexandra Ellert - Tucson AZ, US
Melania Davila - North Alington NJ, US
David Rubin - Danbury CT, US
Rebecca Scully - Seattle WA, US
Clinton Cutchins - Charleston SC, US
Vanessa Mari Lynskey - Seattle WA, US
Allison Hamilton - Seattle WA, US
Robert Christopher Martin - Seattle WA, US
Erika M. Johnson - Seattle WA, US
Tyler E. Benjamin - Arlington TX, US
Heather R. Kanipe - Highland Park IL, US
Adam Joshua Reed - Denver CO, US
Heather L. Hendy - Westminster CO, US
Brendon Alan Kay - Golden CO, US
Trent Vigar - Atlanta GA, US
Taivon David Thompson - Brooklyn NY, US
Samuel Andres Roldan - Astoria NY, US
Lena I. Ripple - Seattle WA, US
Joshua B. Hanson - Marrero LA, US
Olga Kuznetsova - Newcastle WA, US
John Dillon Lareau - Pittsburgh PA, US
Scott J. Wilkins - Seattle WA, US
Michelle Elaine Ruch - Ridgefield WA, US
Jessica Sarmiento Madamba - Elk Grove CA, US
Jia Yin - Jersey City NJ, US

International Classification:

G06Q 10/10
G06Q 10/06
G06Q 40/00

Abstract:

Disclosed are example embodiments of a methods and systems for analyzing and determining impact (or lack thereof) on any selected group or groups of employees of selected pay policies. An example includes a computer-implemented method for analyzing and determining impact on selected group of employees of selected pay policies. The method including receiving a first pay data for the selected group of employees. The method also including determining one or more controls for the selected group of employees. Additionally, the method including calculating an equitable pay range for the selected group of employees based on the one or more controls. The method also including receiving a user input, wherein the user input requests a second pay data relates to an employee, and is based on a selected control. The method also including calculating the second pay data; and sending the second pay data for display.