David A Rubin

US Patent:

6541220, Apr 1, 2003

Filed:

Nov 30, 1999

Appl. No.:

09/449632

Inventors:

David A. Rubin - Needham MA

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C12N 1512

US Classification:

435 691, 536 235, 536 243, 536 2431, 530350, 435 711, 435 712, 435471, 435325, 4353201, 4352523, 43525411

Abstract:

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

US Patent:

7078487, Jul 18, 2006

Filed:

Feb 25, 2003

Appl. No.:

10/372095

Inventors:

Harald Jüppner - Cambridge MA, US
David A Rubin - Needham MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

C07K 14/72
C07K 14/435

US Classification:

530350, 530399

Abstract:

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

US Patent:

20030021391, Jan 30, 2003

Filed:

May 31, 2002

Appl. No.:

10/159795

Inventors:

David Rubin - Delray Beach FL, US
Anthony Kolodzinski - Massapequa Park NY, US

International Classification:

H04M001/24
H04M003/22
H04M003/08

US Classification:

379/022040, 379/022000, 379/001040, 379/024000, 379/027010, 379/029010

Abstract:

The invention provides a system and method for testing a telephone or communications line to determine if the line qualifies for a particular type or class of communications service, for example DSL service. In accordance with one embodiment, a potential customer can download a software program. The program first performs a DSL distance qualification calculation. If the customer's line passes this step, the program determines whether the line coupled between the customer and a central office servicing that customer is electrically qualified for DSL communications. A series of tests to measure signal levels, noise, and other characteristics are performed by a test server, which generally include local loop tests to determine the presence of bridged taps, load coils, and subscriber line concentrators. After the tests are completed, the customer can receive the results, order completion and other instructions.

US Patent:

20050122916, Jun 9, 2005

Filed:

Jan 21, 2005

Appl. No.:

11/040673

Inventors:

David Rubin - Delray Beach FL, US
Anthony Kolodzinski - Massapequa Park NY, US

Assignee:

Fine Point Technologies, Inc. - New York NY

International Classification:

H04B003/36

US Classification:

370293000, 370241000

Abstract:

The invention provides a system and method for testing a telephone or communications line to determine if the line qualifies for a particular type or class of communications service, for example DSL service. In accordance with one embodiment, a potential customer can download a software program. The program first performs a DSL distance qualification calculation. If the customer' line passes this step, the program determines whether the line coupled between the customer and a central office servicing that customer is electrically qualified for DSL communications. A series of tests to measure signal levels, noise, and other characteristics are performed by a test server, which generally include local loop tests to determine the presence of bridged taps, load coils, and subscriber line concentrators. After the tests are completed, the customer can receive the results, order completion and other instructions.

US Patent:

20060228353, Oct 12, 2006

Filed:

May 25, 2006

Appl. No.:

11/440090

Inventors:

David Rubin - Needham MA, US

Assignee:

The General Hospital Corporation - Boston MA

International Classification:

A61K 39/395
C07H 21/04
C12P 21/06
C07K 16/28
C07K 14/72

US Classification:

424143100, 435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.

US Patent:

50757997, Dec 24, 1991

Filed:

Jul 14, 1989

Appl. No.:

7/379842

Inventors:

Jerrold S. Pine - Boca Raton FL
David H. Rubin - Sunrise FL

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

G02B 2702
G08B 522
A45F 500

US Classification:

359896

Abstract:

An apparatus is described for the magnification of an information display on a selective call receiver. The apparatus comprises an optical lens system coupled in a manner which provides for its easy attachment and removal from the selective call receiver.

US Patent:

55218008, May 28, 1996

Filed:

May 22, 1995

Appl. No.:

8/446978

Inventors:

Jerrold S. Pine - Boca Raton FL
David H. Rubin - Boynton Beach FL
Fredrick J. Marquardt - Boynton Beach FL

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

F21V 3300

US Classification:

362 97

Abstract:

A lighting system for use in a conveyer system used for work piece assembly comprising a lifting means (285) having one or more transparent upper lifting members (260) for lifting the work piece (270) and a lighting means (230) positioned below the transparent members and rotatably coupled to the lifting means (285) by a rotating means. The lighting means rotatably extends when the lifting means (285) is raised, thereby providing illumination to the work piece (270), and rotatably retracts when the lifting means (285) is lowered.

US Patent:

51317532, Jul 21, 1992

Filed:

Jul 23, 1990

Appl. No.:

7/565775

Inventors:

Jerrold S. Pine - Boca Raton FL
James C. Robinson - Boynton Beach FL
David H. Rubin - Wellington FL

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

G01B 1114

US Classification:

356375

Abstract:

An automated component placement device (100) includes an automated robotic transporter (108) that transports a component (106) into an illuminated area (104) on a translucent compliant surface (102) upon which components (104) are placed in a three dimensional orientation such that a silhouette of the components, leads, coplanar or non-coplanar are created on the translucent compliant surface (102) when the translucent compliant surface (102) is flexed. The position of silhouette of the component (106) is used to determine the orientation of the component held by the robotic transporter (108) to facilitate the placement of the component (106).