David R Simpson

Address:

2813 Shadblow Ln APT 7, West Columbia, SC 29170

VIN:

1FMEU33EX8UA41531

Make:

FORD

Model:

EXPLORER SPORT TRAC

Year:

2008

US Patent:

6592623, Jul 15, 2003

Filed:

Aug 31, 1999

Appl. No.:

09/386273

Inventors:

Gary L. Bowlin - Mechanicsville VA
Gary Wnek - Midlothian VA
David G. Simpson - Mechanicsville VA
Louis Terracio - Columbia SC

Assignee:

Virginia Commonwealth University Intellectual Property Foundation - Richmond VA

International Classification:

A61F 208

US Classification:

623 1413, 623 1317

Abstract:

A muscle implant includes an extracellular matrix, tendon and muscle cells. The extracellular matrix is made of a matrix of electrospun polymer fibers. The tendon is made of extruded collagen fibers and the muscle cells are disposed on the extracellular matrix in such a manner that the combination of components will functionally and structurally act as normal muscle tissue. Cardiac and smooth muscles may be similarly formed without tendons but including the extracellular matrix and muscle cells.

US Patent:

6787357, Sep 7, 2004

Filed:

Oct 5, 2001

Appl. No.:

09/970651

Inventors:

Gary L. Bowlin - Mechanicsville VA
Gary Wnek - Midlothian VA
David G. Simpson - Mechanicsville VA
Philippe Lam - Richmond VA
Marcus E. Carr - Midlothian VA
Helen Fillmore - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C12N 502

US Classification:

435395, 435325, 435455, 600 36

Abstract:

The invention is directed to use of fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or âorgan-likeâ tissue. A preferred embodiment is a plasma-derived fibrin matrix containing cells.

US Patent:

7374774, May 20, 2008

Filed:

Sep 22, 2003

Appl. No.:

10/668085

Inventors:

Gary L. Bowlin - Mechanicsville VA, US
Gary E. Wnek - Midlothian VA, US
David G. Simpson - Mechanicsville VA, US

Assignee:

Virginia Commonwealth University Intellectual Property Foundation - Richmond VA

International Classification:

A61F 2/02
A61K 9/70
A61K 38/39
C07K 14/78

US Classification:

424423, 424443, 424485, 424486, 530356, 514 12, 514801

Abstract:

The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.

US Patent:

7615373, Nov 10, 2009

Filed:

May 28, 2003

Appl. No.:

10/447670

Inventors:

David G. Simpson - Mechanicsville VA, US
Gary L. Bowlin - Mechanicsville VA, US
Gary E. Wnek - Midlothian VA, US
Peter J. Stevens - Richland Hills TX, US
Marcus E. Carr - Midlothian VA, US
Jamil A. Matthews - Glen Allen VA, US
Saravanamoorthy Rajendran - East Haven CT, US

Assignee:

Virginia Commonwealth University Intellectual Property Foundation - Richmond VA
Organogenesis, Inc. - Canton MA

International Classification:

C12N 5/00
C12N 5/02
A61F 2/02

US Classification:

435398, 623 2372

Abstract:

The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.

US Patent:

7759082, Jul 20, 2010

Filed:

Jan 26, 2004

Appl. No.:

10/764691

Inventors:

Gary L. Bowlin - Mechanicsville VA, US
Gary E. Wnek - Midlothian VA, US
David G. Simpson - Mechanicsville VA, US
Philippe Lam - San Bruno CA, US

Assignee:

Virginia Commonwealth University Intellectual Property Foundation - Richmond VA

International Classification:

C12Q 1/56

US Classification:

435 13

Abstract:

The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.

US Patent:

RE41496, Aug 10, 2010

Filed:

Nov 8, 2006

Appl. No.:

11/594221

Inventors:

David L. Simpson - West Columbia SC, US

International Classification:

G06F 11/00

US Classification:

714727, 714 30, 714733, 714724, 324 731

Abstract:

A boundary-scan circuit method and apparatus for asserting an internal reset signal connected to core logic circuits of an electronic device in order to assure that testing will begin and end in a safe, known logic state. A safe end state is assured even if the system reset signal on an input pin of the electronic device is logically disconnected from the internal reset connection to the core logic, as often occurs in boundary-scan and related testing.

US Patent:

8586345, Nov 19, 2013

Filed:

Mar 21, 2011

Appl. No.:

13/052778

Inventors:

David G. Simpson - Mechanicsville VA, US
Gary L. Bowlin - Mechanicsville VA, US
Gary E. Wnek - Midlothian VA, US
Peter J. Stevens - N. Richland Hills TX, US
Marcus E. Carr - Midlothian TX, US
Jamil A. Matthews - Glen Allen VA, US
Saravanamoorthy Rajendran - East Haven CT, US

Assignee:

Virginia Commonwealth University Intellectual Property Foundation - Richmond VA

International Classification:

C07K 1/00
C12N 5/00
C12N 5/02
A61K 38/17
A61F 2/06

US Classification:

435273, 435398, 435399, 530356, 623 147

Abstract:

The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.

US Patent:

20020042128, Apr 11, 2002

Filed:

Sep 4, 2001

Appl. No.:

09/946158

Inventors:

Gary Bowlin - Mechanicsville VA, US
Gary Wnek - Midlothian VA, US
David Simpson - Mechanicsville VA, US
Philippe Lam - San Bruno CA, US
Marcus Carr - Midlothian VA, US

International Classification:

A61K035/14
A61K009/70
C12N005/08

US Classification:

435/366000, 424/443000, 530/382000

Abstract:

The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.