David Michael Simpson

US Patent:

7179458, Feb 20, 2007

Filed:

Mar 6, 2003

Appl. No.:

10/383834

Inventors:

Chia-Hwa Chang - Mountain View CA, US
David A. Simpson - Redwood City CA, US
Theresa Li-Yun Chang - Los Gatos CA, US
Qiang Xu - Cupertino CA, US
John A. Lewicki - Los Gatos CA, US

Assignee:

Osel, Inc. - Santa Clara CA

International Classification:

A01N 63/00
A61K 48/00

US Classification:

424 932

Abstract:

The present invention relates to species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.

US Patent:

7312076, Dec 25, 2007

Filed:

Jan 5, 2007

Appl. No.:

11/620588

Inventors:

Chia-Hwa Chang - Mountain View CA, US
David A. Simpson - Redwood City CA, US
Theresa Li-Yun Chang - Los Gatos CA, US
Qiang Xu - Cupertino CA, US
John A. Lewicki - Los Gatos CA, US

Assignee:

Osel, Inc. - Santa Clara CA

International Classification:

C12N 15/00

US Classification:

4353201

Abstract:

The present invention relates to species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.

US Patent:

7380031, May 27, 2008

Filed:

Dec 21, 2005

Appl. No.:

11/314915

Inventors:

Jackson Jones - Sunnyvale CA, US
David Simpson - San Jose CA, US
Brian Barnett - Oakland CA, US

Assignee:

LodgeNet Interactive Corporation - Sioux Falls ND

International Classification:

G06F 13/12

US Classification:

710 69, 710 70, 710 72, 725 78, 725 80

Abstract:

A hybrid data distribution system includes a modulator coupled to an analog device, one or more processors coupled to the modulator, and a database coupled to the one or more processors. The database is configured to store encoded data. The system also includes an Ethernet switch for transmitting the encoded data to a digital device. The Ethernet switch is coupled to each of the database and the digital device. Moreover, the one or more processors are configured to directly or indirectly obtain the encoded data from the database, decode the encoded data, and directly or indirectly transmit the decoded data to the modulator. The modulator is configured to transmit the decoded data to the analog device, and the Ethernet switch is configured to directly or indirectly obtain the encoded data from the database, and to transmit the encoded data to the digital device.

US Patent:

7456011, Nov 25, 2008

Filed:

Jan 12, 2006

Appl. No.:

11/331965

Inventors:

Xiaowen Liu - Cupertino CA, US
Kirsten Essenmacher - Palo Alto CA, US
David A. Simpson - Redwood City CA, US
Qiang Xu - Cupertino CA, US

Assignee:

Osel, Inc. - Santa Clara CA

International Classification:

A01N 63/00
A61K 39/02
C12N 1/22
C07K 1/00

US Classification:

4352523, 424 9345, 4242001, 530402

Abstract:

This disclosure relates to a modified version of cyanovirin-N protein and a transformed bacterium that is capable of recombinantly expressing this modified protein. Further disclosed are polynucleotide sequence encoding the modified cyanovirin-N protein, expression cassette that allows the expression of the modified protein, and method of make and use of the modified protein as well as the transformed bacterium. In addition, this disclosure describes two novel promoters originated from , which are capable of directing a high level of gene expression in bacteria. Also described are an expression cassette comprising one of the novel promoters, a genetically modified bacterium containing the expression cassette, a method for recombinant gene expression in bacteria using the novel promoters, and a method for delivery of proteins with desired biological activity to a mucosal surface in a human.

US Patent:

7747612, Jun 29, 2010

Filed:

Oct 31, 2005

Appl. No.:

11/264292

Inventors:

Christopher Thun - Palo Alto CA, US
Jackie Andrew Freeman - San Jose CA, US
Tony Sang-min Lee - Palo Alto CA, US
Gregory M. Makris - Mountain View CA, US
David Simpson - San Francisco CA, US
David M. Ciemiewicz - Mountain View CA, US
Hal Schectman - Portola Valley CA, US
Apostolos Karmirantzos - Sunnyvale CA, US
James Michael Reinhold - Berkeley CA, US

Assignee:

Yahoo! Inc. - Sunnyvale CA

International Classification:

G06F 17/30

US Classification:

707722, 707707

Abstract:

The present invention is directed towards systems and methods for generating and displaying the difference between a primary result set and a secondary result set. According to the present invention, a method for displaying the difference between a primary result set and a secondary result set for a query comprises generating a primary result set and a secondary result set, the primary result set and secondary result set generated according to one or more respective disparate search algorithms. A difference result set is determined according to a difference between items in the primary result set and second result set, which is displayed to a user.

US Patent:

7747614, Jun 29, 2010

Filed:

Oct 31, 2005

Appl. No.:

11/264740

Inventors:

Jackie Andrew Freeman - San Jose CA, US
Tony Sang-min Lee - Palo Alto CA, US
David M. Ciemiewicz - Mountain View CA, US
Hal Schectman - Portola Valley CA, US
Apostolos Karmirantzos - Sunnyvale CA, US
James Michael Reinhold - Berkeley CA, US
David Simpson - San Francisco CA, US
Gregory M. Makris - Mountain View CA, US

Assignee:

Yahoo! Inc. - Sunnyvale CA

International Classification:

G06F 17/30

US Classification:

707722, 707707

Abstract:

The present invention is directed towards systems and methods for generating and displaying the difference between a primary result set and a secondary result set. According to the present invention, a method for displaying the difference between a primary result set and a secondary result set for a query comprises generating a primary result set and a secondary result set, the primary result set and secondary result set generated according to one or more respective disparate search algorithms. A difference result set is determined according to a difference between items in the primary result set and second result set, which is displayed to a user.

US Patent:

7833791, Nov 16, 2010

Filed:

Nov 9, 2007

Appl. No.:

11/938044

Inventors:

Chia-Hwa Chang - Mountain View CA, US
David A. Simpson - Redwood City CA, US
Theresa Li-Yun Chang - Los Gatos CA, US
Qiang Xu - Cupertino CA, US
John A. Lewicki - Los Gatos CA, US

Assignee:

Osel, Inc. - Santa Clara CA

International Classification:

C12N 15/00

US Classification:

435455

Abstract:

The present invention relates to species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.

US Patent:

8349600, Jan 8, 2013

Filed:

Jan 6, 2006

Appl. No.:

11/327195

Inventors:

Patrick K. Martin - Redwood City CA, US
David A. Simpson - Redwood City CA, US

Assignee:

Applied Biosystems, LLC - Carlsbad CA

International Classification:

C12N 9/12

US Classification:

435194, 435183, 530350

Abstract:

Polypeptides having nucleic acid binding activity are provided. Methods of stabilizing a nucleic acid duplex are provided. Methods of promoting the annealing of complementary nucleic acid strands are provided. Methods of increasing the processivity of a DNA polymerase are provided. Methods of enhancing the activity of a nucleic acid modification enzyme are provided. Fusion proteins are provided. Methods of using fusion proteins are provided. Kits are provided.