David Lem Simpson

US Patent:

8637651, Jan 28, 2014

Filed:

Mar 15, 2010

Appl. No.:

12/724403

Inventors:

Kirk E. Apt - Ellicott City MD, US
James Casey Lippmeier - Columbia MD, US
David Simpson - Boulder CO, US
Jun Wang - Cooksville MD, US
James P. Wynn - Columbia MD, US
Ross Zirkle - Mt. Airy MD, US

Assignee:

DSM IP Assets B.V. - Te Heerlen

International Classification:

C07H 21/04
C12P 21/02

US Classification:

536 231, 435 691

Abstract:

The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.

US Patent:

20100266564, Oct 21, 2010

Filed:

Mar 19, 2010

Appl. No.:

12/727851

Inventors:

Kirk E. Apt - Ellicott City MD, US
Leslie Richter - Broomfield CO, US
David Simpson - Boulder CO, US
Ross Zirkle - Mt. Airy MD, US

International Classification:

C12N 15/52
C12N 15/63
C12N 5/10
C12N 1/00
C12P 7/64
C12N 9/00
A61K 38/43
A61K 48/00
A61P 3/00

US Classification:

424 941, 536 232, 4353201, 435419, 435243, 435325, 435134, 435183, 514 44 R

Abstract:

The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.

US Patent:

20220361841, Nov 17, 2022

Filed:

Jul 25, 2022

Appl. No.:

17/872203

Inventors:

- San Diego CA, US
Francois Guy Gerard Marie VIGNON - ANDOVER MA, US
David HOPE SIMPSON - BOTHELL WA, US
Andrew HANCOCK - SACRAMENTO CA, US
Sheng-Wen HUANG - OSSINING NY, US

International Classification:

A61B 8/12
A61B 8/08
A61B 8/00

Abstract:

Systems, methods, and devices that perform flow scan sequences are provided. In one embodiment, an ultrasound imaging system includes an intraluminal catheter or guidewire, an annular array of acoustic elements positioned around a circumference of the catheter or guidewire, and a processor in communication with the annular array. The processor is configured to activate a first subaperture of the annular array at a first time, thereafter, activate a second interleaving subaperture, and activate the first subaperture again at a different, second time such that the scan sequence moves around the circumference of the catheter or guidewire. Temporal differences between the received ultrasound signals obtained by the first subaperture at the first and second times are determined to detect motion around the annular array. By interleaving subaperture firings, the total number of firings to form an image frame can be reduced.

US Patent:

20220354465, Nov 10, 2022

Filed:

Jul 19, 2022

Appl. No.:

17/867997

Inventors:

- Eindhoven, NL
Seungsoo KIM - ANDOVER MA, US
Francois Guy Gerard Marie VIGNON - ANDOVER MA, US
David HOPE SIMPSON - BOTHELL WA, US

International Classification:

A61B 8/08
A61B 8/14
A61B 8/00
G01S 7/52

Abstract:

Improved ultrasound imaging devices and methods of operating the devices that minimize grating lobe artifacts in an ultrasound image are provided. For example, an ultrasound imaging system analyzes the ultrasound data at different frequency bands and generates a grating-lobe-minimized image based on minimum signals identified for each pixel among the plurality of frequency ranges. In one embodiment, an ultrasound imaging system includes an ultrasound transducer array configured to obtain ultrasound data, and a processor in communication with the ultrasound transducer array. The processor is configured to receive the ultrasound data, generate an ultrasound image based on a first frequency range of the ultrasound data, generate a grating-lobe-minimized ultrasound image based on a plurality of second frequency ranges of the ultrasound data, combine the ultrasound image and the grating-lobe-minimized ultrasound image to generate a combined ultrasound image, and output the combined ultrasound image to a display.

US Patent:

20220326951, Oct 13, 2022

Filed:

Jun 29, 2022

Appl. No.:

17/852821

Inventors:

- San Mateo CA, US
David Simpson - Los Angeles CA, US

International Classification:

G06F 9/30

Abstract:

A new device executing an application on a new central processing unit (CPU), determines whether the application is for a legacy device having a legacy CPU. When the new device determines that the application is for the legacy device, it executes the application on the new CPU with selected available resources of the new device restricted to approximate or match a processing behavior of the legacy CPU, e.g., by reducing a usable portion of a return address stack of the new CPU and thereby reducing a number of calls and associated returns that can be tracked

US Patent:

20230085700, Mar 23, 2023

Filed:

Nov 22, 2022

Appl. No.:

17/992423

Inventors:

- Eindhoven, NL
Shiying Wang - Melrose MA, US
Sheng-Wen Huang - Ossining NY, US
Francois Guy Gerard Marie Vignon - Andover MA, US
Keith William Johnson - Lynnwood WA, US
Liang Zhang - Issaquah WA, US
David Hope Simpson - Bothell WA, US

International Classification:

A61B 8/06
A61B 8/00
A61B 8/08

Abstract:

A system for visualization and quantification of ultrasound imaging data according to embodiments of the present disclosure may include a display unit, and a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to estimate axial and lateral velocity components of the fluid flowing within the bodily structure, determine a plurality of flow directions within the image based on the axial and lateral velocity components, differentially encode the flow directions based on flow direction angle to generate a flow direction map, and cause the display unit to concurrently display the image including the bodily structure overlaid with the flow direction map.

US Patent:

20230092997, Mar 23, 2023

Filed:

Sep 19, 2022

Appl. No.:

17/933452

Inventors:

- Chelmsford MA, US
Bryan Crompton - Lowell MA, US
Junaid Islam - San Jose CA, US
David Simpson - Springfield VA, US
Dap Minh Tran - Lowell MA, US
Tommaso Melodia - Newton MA, US

International Classification:

H04L 47/10
H04L 47/30
H04L 47/2425
H04L 43/08

Abstract:

A method of dynamically routing packets to a destination node performed by a computing device is disclosed. The method includes: (1) detecting a status of a plurality of links to the destination node across a plurality of communications modalities; (2) determining a set of links to use for routing packets to the destination node based on the detected statuses; and (3) sending packets to the destination node via the determined set of links. A related computer program product, apparatus, and system are also disclosed.

US Patent:

20230050732, Feb 16, 2023

Filed:

Nov 1, 2022

Appl. No.:

17/978697

Inventors:

- San Diego CA, US
Yiqun YANG - SACRAMENTO CA, US
David HOPE SIMPSON - BOTHELL WA, US
Francois Guy Gerard Marie VIGNON - ANDOVER MA, US
Jun Seob SHIN - WINCHESTER MA, US

International Classification:

A61B 8/08
A61B 8/12
A61B 8/14
A61B 8/00

Abstract:

Ultrasound imaging systems and methods for generated clutter-reduced images are provided. For example, an ultrasound imaging system can include an array of acoustic elements in communication with a processor. The processor is configured to activate the array to perform a scan sequence to obtain a plurality of signals, identify off-axis signals from the plurality of signals by comparing the right subaperture and the left subaperture, and create a clutter-reduced image based on the comparison. Because off-axis signals are more likely to create image clutter, reducing the influence of off-axis signals on the image can therefore improve the quality of the image. Accordingly, embodiments of the present disclosure provide systems, methods, and devices for generating ultrasound images that have reduced or minimized clutter, even for images obtained using arrays that do not satisfy the Nyquist criterion.