David M Spencer

US Patent:

6758509, Jul 6, 2004

Filed:

May 20, 2003

Appl. No.:

10/441175

Inventors:

David C. Spencer - Houston TX 77091

International Classification:

B60R 504

US Classification:

296 376, 29610006

Abstract:

A pick-up bed space divider includes a device for removably positioning in a pick-up bed. The pick-up bed has a bottom wall, a pair of side walls, and a tailgate. The bottom wall has a pair of wheel wells. The device has a first panel having an upper edge, a bottom edge and a pair of side edges. The bottom edge is selectively abutted against the bottom wall and positioned adjacent to the wheel wells. A second panel has a back edge, a front edge, and a pair of lateral edges. A hinge is attached to and pivotally couples the back edge to the upper edge. The second panel has a width between the lateral edges that is greater than a width between the side walls. The second panel abuts an upper edge of the side walls and the tailgate when the second panel is in a horizontal position.

US Patent:

6891021, May 10, 2005

Filed:

Nov 13, 2001

Appl. No.:

10/054712

Inventors:

Gerald R. Crabtree - Woodside CA, US
Stuart L. Schreiber - Cambridge MA, US
David M. Spencer - Los Altos CA, US
Thomas J. Wandless - Cambridge MA, US
Peter Belshaw - Somerville MA, US

Assignee:

Board of Trustees of the Leland Stanford Junior University - Stanford CA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C07K002/00
C07K004/00

US Classification:

530350, 530300, 435 71, 435 72

Abstract:

We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.

US Patent:

6972193, Dec 6, 2005

Filed:

Dec 17, 1999

Appl. No.:

09/466568

Inventors:

Gerald R. Crabtree - Woodside CA, US
Stuart L. Schreiber - Boston MA, US
David M. Spencer - Houston TX, US
Thomas J. Wandless - Menlo Park CA, US
Steffan N. Ho - San Diego CA, US
Peter Belshaw - Somerville MA, US

Assignee:

Board of Trustees of Leland Stanford Junior University - Stanford CA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C12N005/10
C12N015/62
C12N015/63

US Classification:

435325, 4353201, 435419, 536 234

Abstract:

Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins.

US Patent:

7404950, Jul 29, 2008

Filed:

Feb 18, 2004

Appl. No.:

10/781384

Inventors:

David Spencer - Houston TX, US
Brent Hanks - Houston TX, US
Kevin Slawin - Houston TX, US

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

A61K 48/00
C07H 21/04

US Classification:

424 9321, 424 931, 424 932, 536 231, 536 234, 514 44

Abstract:

The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.

US Patent:

7754202, Jul 13, 2010

Filed:

Jan 7, 1999

Appl. No.:

09/582916

Inventors:

Carl Anthony Blau - Seattle WA, US
David M. Spencer - Houston TX, US

Assignee:

Stanford University - Palo Alto CA
University of Washington - Seattle WA

International Classification:

A61K 48/00
C12N 5/00
C12N 15/63

US Classification:

424 9321, 514 44 R, 435325, 4353201, 435455

Abstract:

This invention involves methods and materials for conferring a direct proliferative advantage on a genetically modified subpopulation of cells. Selection is then accomplished by exerting a positive selective stimulus on the engineered cells rather than a negative pressure on nonengineered cells.

US Patent:

7763820, Jul 27, 2010

Filed:

Nov 27, 2007

Appl. No.:

11/986830

Inventors:

David B. Spencer - Bedford MA, US
R. Lynn Conley - Nashville TN, US
Richard E. Hill - Nashville TN, US
Robert H. Parrish - Nashville TN, US
Charles E. Roos - Nashville TN, US

Assignee:

Spectramet, LLC - Wilmington DE

International Classification:

B07C 5/00

US Classification:

209576, 209579, 209589, 356316, 356318, 378 45, 378 47

Abstract:

A piece of material that includes low-Z elements is classified based on photonic emissions detected from the piece of material. Both XRF spectroscopy and OES techniques, for example, Laser-Induced Breakdown Spectroscopy (LIBS) and spark discharge spectroscopy, may be used to classify the piece of material. A stream of pieces of material are moved along a conveying system into a stimulation and detection area. Each piece of material, in turn, is stimulated with a first and second stimulus, of a same or different type, causing the piece of material to emit emissions, for example, photons, which may include at least one of x-ray photons (i. e. , x-rays) and optical emissions. These emissions then are detected by one or more detectors of a same or different type. The piece of materials is then classified, for example, using a combination of hardware, software and/or firmware, based on the detected emissions, and then sorted.

US Patent:

8084596, Dec 27, 2011

Filed:

Jan 7, 2010

Appl. No.:

12/684064

Inventors:

Gerald R. Crabtree - Woodside CA, US
Peter Belshaw - Somerville MA, US
Stuart L. Schreiber - Boston MA, US
David M. Spencer - Houston TX, US
Thomas J. Wandless - Palo Alto CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA
President and Fellows of Harvard College - Cambridge MA

International Classification:

C07H 21/04
C12N 15/63
C12N 15/85

US Classification:

536 234, 4353201, 435325

Abstract:

We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.

US Patent:

8486693, Jul 16, 2013

Filed:

Sep 19, 2012

Appl. No.:

13/622501

Inventors:

Dongsu Park - Houston TX, US
David Spencer - Houston TX, US
Natalia Lapteva - Houston TX, US

Assignee:

Bellicum Pharmaceuticals, Inc. - Houston TX

International Classification:

C12N 5/00
C12N 5/07
C12N 5/0784
C12N 5/10

US Classification:

435325, 435355, 435362, 435363, 424 931, 424 9321

Abstract:

Modified antigen presenting cells provided herein have improved lifespan and immunogenicity compared to unmodified antigen presenting cells, and are useful for immunotherapy. The modified antigen presenting cells express an altered protein kinase, referred to herein as “Akt. ” The altered Akt associates with the cell membrane with greater frequency than unaltered Akt, and is referred to herein as “membrane-targeted Akt. ”.