David L Sternberg

US Patent:

7476516, Jan 13, 2009

Filed:

Jul 25, 2003

Appl. No.:

10/627124

Inventors:

Maria Tang - Fairfield CA, US
Alan Sloma - Davis CA, US
David Sternberg - Davis CA, US
Regine Behr - Roseville CA, US

Assignee:

Novozymes, Inc. - Davis CA

International Classification:

C12P 21/06

US Classification:

435 691, 435 693, 435 697, 435 711, 435243, 4352521, 4352523, 43525231

Abstract:

The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent cell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological substance and a second nucleic acid sequence comprising a modification of at least one of the genes cypX and yvmC, which are involved in the production of a red pigment, and (ii) the mutant cell is deficient in the production of the red pigment compared to the parent cell when cultivated under the same conditions; and (b) recovering the heterologous biological substance from the cultivation medium. The present invention also relates to mutants of cells and methods for producing the mutants.

US Patent:

7666625, Feb 23, 2010

Filed:

Dec 9, 2008

Appl. No.:

12/331323

Inventors:

Maria Tang - Fairfield CA, US
Alan Sloma - Davis CA, US
David Sternberg - Davis CA, US
Linda Sternberg, legal representative - Davis CA, US
Regine Behr - Roseville CA, US

Assignee:

Novozymes, Inc. - Davis CA

International Classification:

C12P 21/06

US Classification:

435 691, 435 693, 435 697, 435 711, 435243, 4352521, 4352523, 43525231

Abstract:

The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent cell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological substance and a second nucleic acid sequence comprising a modification of at least one of the genes cypX and yvmC, which are involved in the production of a red pigment, and (ii) the mutant cell is deficient in the production of the red pigment compared to the parent cell when cultivated under the same conditions; and (b) recovering the heterologous biological substance from the cultivation medium. The present invention also relates to mutants of cells and methods for producing the mutants.

US Patent:

8124376, Feb 28, 2012

Filed:

Feb 10, 2010

Appl. No.:

12/703550

Inventors:

Maria Tang - Fairfield CA, US
Alan Sloma - Davis CA, US
Leslie Naggiar, legal representative - Suffern NY, US
David Sternberg - Davis CA, US
Linda Sternberg, legal representative - Davis CA, US
Regine Behr - Roseville CA, US

Assignee:

Novozymes, Inc. - Davis CA

International Classification:

C12P 21/06

US Classification:

435 691, 435243, 4352521, 4352523, 43525231, 435 693, 435 697, 435 711

Abstract:

The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent cell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological substance and a second nucleic acid sequence comprising a modification of at least one of the genes cypX and yvmC, which are involved in the production of a red pigment, and (ii) the mutant cell is deficient in the production of the red pigment compared to the parent cell when cultivated under the same conditions; and (b) recovering the heterologous biological substance from the cultivation medium. The present invention also relates to mutants of cells and methods for producing the mutants.