David Stevenson

US Patent:

6350275, Feb 26, 2002

Filed:

Jun 9, 1998

Appl. No.:

09/094231

Inventors:

Hendrik J. Vreman - Los Altos CA
David K. Stevenson - Los Altos CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61N 506

US Classification:

607 88, 607 91

Abstract:

A device is provided for treating a circadian rhythm disorder in a subject. The device includes a plurality of light emitting diodes (LEDs), preferably blue to green; a mounting to which the LEDs are connected: a material for positioning the LEDs within 3 cm of the subject, with an orientation toward the subject; a portable power supply electrically connected to the LEDs; and a control connected to the LEDs for altering the operation of the LEDs. The device is sufficiently light and compact to be comfortably worn by the subject. One or more such devices are used to deliver light to a subjects retinas, to the subjects vascular tissue, or simultaneously to both the retinas and the vascular tissue. For illumination of the retina, small chip-type LEDs are integrated into the frames of eyeglasses and positioned to direct light into the eyes of the subject. For illumination of the vascular tissue, an array of lens or chip type LEDs are contained in a casing that is secured against the skin of the subject.

US Patent:

6596016, Jul 22, 2003

Filed:

Apr 19, 2000

Appl. No.:

09/551946

Inventors:

Hendrik J. Vreman - Los Altos CA
Daniel S. Seidman - Tel-Aviv, IL
David K. Stevenson - Los Altos Hills CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

A61N 506

US Classification:

607 88, 607 91, 2906, 600310, 600315, 128903, 128904

Abstract:

A phototherapy garment contains a flexible backing material, a transparent liner, and a flexible printed circuit sheet containing surface-mounted light-emitting diodes (LEDs) positioned between the backing material and the liner. An infant is placed inside the garment so that the LEDs illuminate a large portion of the infants skin for phototherapy. The LEDs preferably emit high-intensity blue light, suitable for treatment of neonatal hyperbilirubinemia or Crigler-Najjar syndrome. The LEDs are arranged in a densely packed array facing the liner and emit uniform, high intensity light. A power supply, which may be portable, supplies adjustable power to the LEDs, preferably pulsed with a duty cycle of approximately 10%, and preferably to overdrive the LEDs to maximize light output. A two-way communications device incorporated into the garment allows a physician or computer to control the garment remotely and gather relevant information periodically or continuously. The garment may also contain a feedback system with skin bilirubin sensors, so that the intensity level and duration of light therapy can be based on bilirubin in the skin, which is a reflection of the newborns serum bilirubin concentration.

US Patent:

43892744, Jun 21, 1983

Filed:

Mar 23, 1981

Appl. No.:

6/246529

Inventors:

David A. Stevenson - Los Altos Hills CA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C30B 1900

US Classification:

156624

Abstract:

A method for removing residual oxygen from a growth solution prior to liq phase epitaxial crystal growth comprising the steps of disposing the materials in a containment vessel of a solid oxide electrolyte material under a protective atmosphere, heating the materials to form a liquid charge in the containment vessel, placing an electrode of an inert conducting solid in physical contact with the liquid charge, and applying a DC electric potential between the electrode and the containment vessel, the electrical contact to the containment vessel being made through a porous metallic coating of an inert metal on the outside surface of the containment vessel in the region where the liquid charge is contiguous to the inside surface of the containment vessel, the porous coating being relatively positive and the electrode being relatively negative.

US Patent:

47915501, Dec 13, 1988

Filed:

Sep 30, 1987

Appl. No.:

7/103123

Inventors:

David R. Stevenson - Los Altos Hills CA
Michael T. Devlin - Sunnyvale CA

Assignee:

Rational - Santa Clara CA

International Classification:

G06F 944

US Classification:

364200

Abstract:

A higher order language-directed computer architecture particularly adaptable for fourth generation program languages. The computer includes a memory which stores package modules and task modules for programs, each of which includes a control segment representing control for the module, a code segment representing instructions for the computer relating to the module, a data segment, a type segment representing type descriptors declared for the module, a queue segment containing synchronization messages for controlling queuing between task modules and an import segment containing lists of objects outside a module which are accessible within the module. The computer simultaneously manipulates portions of the segments based on instructions in the code segment.

US Patent:

43714200, Feb 1, 1983

Filed:

Mar 9, 1981

Appl. No.:

6/241997

Inventors:

David A. Stevenson - Los Altos Hills CA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C30B 904

US Classification:

156624

Abstract:

In a process for growth of a layer of semiconductor material by precipitation from a solution of the semiconductor material in a solvent by liquid phase epitaxial growth (LPE), the improvement is the step of adding from approximately 0. 01% to 1. 0% by weight of a material which forms a stable oxide or sulfide and is soluble in the solvent to the solution prior to the step of precipitating the semiconductor layer to eliminate the deleterious effects of residual oxygen. A relatively short annealing time is required to dissolve the addition in the solvent and allow the addition to react with dissolved oxygen or other impurities before a conventional LPE growth process may be initiated, although high temperature anneals of varying length may precede or follow the addition of the oxide-forming or sulfide-forming material. Zirconium, titanium, vanadium, scandium, yttrium, and aluminum are in general suitable for use as the oxide-forming material.

US Patent:

53834690, Jan 24, 1995

Filed:

Oct 12, 1993

Appl. No.:

8/135142

Inventors:

Hendrik J. Vreman - Los Altos CA
David K. Stevenson - Palo Alto CA

Assignee:

Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61B 508

US Classification:

128719

Abstract:

Apparatus for use in a hospital nursery, clinic, or physician's office for the sampling and analysis of neonatal end-tidal breath for carbon monoxide as an indication of hemolysis and subsequent infant jaundice includes a syringe and plunger for collecting end-tidal breath, a pump for supporting the syringe and including drive means for incrementally withdrawing the plunger and collecting end tidal breath, and a controller for the pump including a thermistor positionable to respond to the temperature of exhaled breath and generating an electrical signal in response to thermistor temperature. A rate detector receives the signal and determines exhalation rate. The signal is delayed in response to exhalation rate and then utilized to energize the pump in incrementally withdrawing the plunger in collecting end tidal breath. The pump can also be used in analysis equipment which extracts the end tidal breath sample with a sensor receiving the sample and determining carbon monoxide content. Alternatively, separate pumps can be employed for the sample collection and for the sample analysis.

US Patent:

48310247, May 16, 1989

Filed:

Oct 15, 1987

Appl. No.:

7/108743

Inventors:

Hendrik J. Vreman - Los Altos CA
David K. Stevenson - Palo Alto CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

A61K 31555
A61K 4900

US Classification:

514185

Abstract:

Disclosed herein is an effective and safe method for preventing the onset of neonatal jaundice through the reduction of bilirubin production. This method can be applied to populations of infants based on mass screening procedures predictive of development of the disease. The most effective of these screening methods measures carbon monoxide production by the infants using a simple breath test.

US Patent:

50811150, Jan 14, 1992

Filed:

Mar 24, 1989

Appl. No.:

7/328205

Inventors:

Hendrik J. Vreman - Los Altos CA
David K. Stevenson - Palo Alto CA

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

A61K 31555
C07D48722

US Classification:

514185

Abstract:

A formulation for administration of a metalloporphyrin compound useful in the treatment or prevention of jaundice is described. The formulation comprises the metalloporphyrin in admixture with an excipient which is a water-soluble organic amine, said composition having been neutralized to neutral pH. The formulation may advantageously contain a stabilizer, such as human serum albumin.