David S Stokes

US Patent:

6653134, Nov 25, 2003

Filed:

Feb 24, 1998

Appl. No.:

09/028395

Inventors:

Darwin J. Prockop - Philadelphia PA
David G. Stokes - Willow Grove PA
S. Ausim Azizi - Philadelphia PA

Assignee:

CP Hahnemann University - Philadelphia PA

International Classification:

C12N 500

US Classification:

435377, 435366, 435368, 435372, 435373

Abstract:

Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and administering the isolated stromal cells to the central nervous system of the human patient, wherein the presence of the isolated stromal cells in the brain effects treatment of the disease, disorder or condition. Stromal cells which are isolated may be cultured in vitro, they may be genetically engineered to produce therapeutic compounds, and/or they may be pre-differentiated prior to administration into the central nervous system.