David M Sullivan

US Patent:

20050042698, Feb 24, 2005

Filed:

Mar 28, 2003

Appl. No.:

10/502834

Inventors:

Plamen Demirev - Ellicott City MD, US
Andrew Feldman - Columbia MD, US
Nirbhay Kumar - Bethesda MD, US
Peter Scholl - Baltimore MD, US
David Sullivan - Baltimore MD, US

International Classification:

G01N033/53
G01N033/569

US Classification:

435007220

Abstract:

Mass spectrometric techniques are provided for detecting the presence of parasites that accumulate unbound heme in red blood cells (including malaria parasites), based on the discovery that unbound heme can be detected and quantified using mass spectrometry. In one aspect of the invention, the method includes the steps of: obtaining a blood sample from the animal; preparing a test sample on a support from the blood sample, and inserting the support into a mass spectrometer for analysis. Next one obtains a mass spectrum of the test sample and determines whether the mass spectrum contains a mass/charge signature of unbound heme. If it is determined that the mass spectrum of the test sample shows the mass/charge signature of unbound heme, the animal is diagnosed as infected with malaria parasites.

US Patent:

20080193499, Aug 14, 2008

Filed:

Jun 27, 2005

Appl. No.:

11/630596

Inventors:

Jun Liu - Clarksville MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61F 2/00
A61K 31/513
A61K 31/343
A61K 31/58
A61K 31/4196
A61K 31/506
A61K 9/00
A61K 38/50
A61K 31/496

US Classification:

424423, 514274, 514470, 514176, 424 946, 51425407, 424484, 514383, 514256

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

US Patent:

20090117602, May 7, 2009

Filed:

Jan 25, 2006

Appl. No.:

11/883130

Inventors:

David J. Sullivan - Baltimore MD, US
Peter Scholl - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12Q 1/44
C12Q 1/02
C12Q 1/32
C12M 1/00

US Classification:

435 19, 435 29, 435 26, 4352871

Abstract:

This invention relates to assays for a analyte in a liquid sample such as a body fluid. More particularly, the invention relates to a method and apparatus for the detection of a ligand in a body fluid such as urine or blood, which can diagnose malarial infection.

US Patent:

20100330148, Dec 30, 2010

Filed:

Mar 20, 2007

Appl. No.:

12/225391

Inventors:

Jun O. Liu - Clarksville MD, US
Curtis Robert Chong - Honolulu HI, US
David J. Sullivan - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61M 31/00
A61K 38/50
A61K 31/7052
A61K 31/4174
A61K 31/496
A61K 31/4196
A61K 31/506
A61K 31/7072
A61K 31/58
A61P 35/00
A61P 17/00
A61P 7/10
A61P 19/02
A61P 29/00
A61P 3/00

US Classification:

424427, 424 946, 514 43, 514396, 514399, 51425407, 514383, 514256, 514 50, 514176

Abstract:

Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject.

US Patent:

20130101657, Apr 25, 2013

Filed:

Sep 26, 2012

Appl. No.:

13/627939

Inventors:

The Johns Hopkins University - Baltimore MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 31/58
A61K 45/06
A61F 9/00

US Classification:

424427, 514176

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.

US Patent:

20150056267, Feb 26, 2015

Filed:

Oct 31, 2014

Appl. No.:

14/530398

Inventors:

- Baltimore MD, US
Curtis Chong - Baltimore MD, US
David J. Sullivan - Baltimore MD, US

International Classification:

A61K 31/58
A61F 9/00
A61K 45/06

US Classification:

424427, 514176

Abstract:

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.