David D Swenson

US Patent:

20210285025, Sep 16, 2021

Filed:

Dec 22, 2020

Appl. No.:

17/130394

Inventors:

- Sunnyvale CA, US
David H. Persing - San Martin CA, US
Alan Wortman - Redwood City CA, US
Ronald Chang - Redwood City CA, US
David Swenson - Santa Clara CA, US

International Classification:

C12Q 1/686
C12Q 1/6851
C12Q 1/6848
B01L 3/00
B01L 7/00
C12Q 1/689

Abstract:

The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.

US Patent:

20210071236, Mar 11, 2021

Filed:

Nov 9, 2020

Appl. No.:

17/092629

Inventors:

- San Jose CA, US
Victor BRIONES - Gilroy CA, US
Ryan T. CENA - San Jose CA, US
Adam DE LA ZERDA - Los Altos CA, US
Colin KELLY - San Francisco CA, US
Gregory LONEY - Los Altos CA, US
Gary SCHOOLNIK - Palo Alto CA, US
David SWENSON - Santa Clara CA, US

Assignee:

Visby Medical, Inc. - San Jose CA

International Classification:

C12Q 1/6806
C12Q 1/686
B01L 3/00
B01L 7/00

Abstract:

A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.

US Patent:

20190169677, Jun 6, 2019

Filed:

Nov 9, 2018

Appl. No.:

16/186067

Inventors:

- San Jose CA, US
Victor BRIONES - Gilroy CA, US
Ryan T. CENA - San Jose CA, US
Adam DE LA ZERDA - Palo Alto CA, US
Colin KELLY - San Francisco CA, US
Gregory LONEY - Los Altos CA, US
Gary SCHOOLNIK - Palo Alto CA, US
David SWENSON - Santa Clara CA, US

Assignee:

Click Diagnostics, Inc. - San Jose CA

International Classification:

C12Q 1/6806
C12Q 1/686
B01L 3/00
B01L 7/00

Abstract:

A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.

US Patent:

20180187243, Jul 5, 2018

Filed:

Dec 20, 2017

Appl. No.:

15/849125

Inventors:

- Sunnyvale CA, US
David H. Persing - San Martin CA, US
Alan Wortman - Redwood City CA, US
Ronald Chang - Redwood City CA, US
David Swenson - Santa Clara CA, US

International Classification:

C12Q 1/686
B01L 7/00
C12Q 1/689
C12Q 1/6848
B01L 3/00
C12Q 1/6851

Abstract:

The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.

US Patent:

20150176057, Jun 25, 2015

Filed:

Nov 25, 2014

Appl. No.:

14/553622

Inventors:

- Sunnyvale CA, US
David H. Persing - San Martin CA, US
Alan Wortman - Redwood City CA, US
Ronald Chang - Redwood City CA, US
David Swenson - Santa Clara CA, US

International Classification:

C12Q 1/68
B01L 3/00
B01L 7/00

Abstract:

The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from a single sample by carrying out under closed-loop control successive amplifications of different target polynucleotides from different portions of the sample.