David Minh Tran

US Patent:

20180372724, Dec 27, 2018

Filed:

Jun 26, 2018

Appl. No.:

16/019332

Inventors:

- Oakland CA, US
- Hong Kong, CN
Tang Wai Ronald Adolphus Li - Pok Fu Lam, HK
David Dan Tran - Aliso Viejo CA, US

International Classification:

G01N 33/50
G06F 19/24

Abstract:

A platform configured to predict type or family of an unknown drug candidate compound, the platform including: a living cell or a tissue; a detector that measures an indicator of a cellular response by the living cell or tissue upon exposure to the unknown drug candidate compound; a memory configured to store data related to the indicator of the cellular response detected by the detector from a library of drug types and/or families; and one or more processing unit(s) configured to: process the data related to the indicator of the cellular response of the living cell or tissue upon exposure to the unknown drug candidate compound, and compare cellular response data from the library of drug types and/or families, so that a drug type and/or a drug family and/or a mechanism of action of the unknown drug candidate compound can be predicted on the basis of a similarity between the detected cellular response data of the unknown drug candidate compound and the cellular response data of the library of drug types and/or families. Also disclosed are methods of screening an unknown drug, including: comparing the data measured from a test cell to corresponding cellular response data in a library of known drug types, and determining a relationship between the unknown drug and a known drug type or a known drug family to predict the type or family of the unknown drug.