David J Waterhouse from 47 Dewitt Ln, Millstone, NJ 08844, age 53, Phone: 9083693480

Resumes

David Waterhouse

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Location:

Greater New York City Area

Industry:

Biotechnology

Us Patents

Methods For Separation And Detection Of Ketosteroids And Other Carbonyl-Containing Compounds
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US Patent:

7807472, Oct 5, 2010
Filed:

Apr 15, 2003
Appl. No.:

10/511409
Inventors:

Xia Xu - Frederick MD, US
Regina G. Ziegler - Bethesda MD, US
David J. Waterhouse - Frederick MD, US
Joseph E. Saavedra - Thurmont MD, US
Larry K. Keefer - Bethesda MD, US
Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:

G01N 33/00
G01N 1/00
US Classification:

436 87, 436173, 436817, 4352871
Abstract:

Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.

Polydiazeniumdiolated Cyclic Polyamines With Polyphasic Nitric Oxide Release And Related Compounds, Compositions Comprising Same And Methods Of Using Same
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US Patent:

7928096, Apr 19, 2011
Filed:

Nov 11, 2008
Appl. No.:

12/268855
Inventors:

David J. Waterhouse - Hillsborough NJ, US
Preeya Kapur - Frederick MD, US
Larry K. Keefer - Bethesda MD, US
Joseph A. Hrabie - Frederick MD, US
Frank De Rosa - Frederick MD, US
Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Services - Bethesda MA
International Classification:

A61K 31/33
C07D 255/02
C07D 257/02
C07D 259/00
US Classification:

514183, 540474
Abstract:

The present invention provides compound of the formula (I):.

Polydiazeniumdiolated Cyclic Polyamines With Polyphasic Nitric Oxide Release And Related Compounds, Compositions Comprising Same And Methods Of Using Same
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US Patent:

20050148566, Jul 7, 2005
Filed:

Nov 5, 2004
Appl. No.:

10/982576
Inventors:

David Waterhouse - Hillsborough NJ, US
Preeya Kapur - Frederick MD, US
Larry Keefer - Bethesda MD, US
Joseph Hrabie - Frederick MD, US
Frank Rosa - Frederick MD, US
Assignee:

The Government of the USA, as Rep. by the Secretary, Dept. of Health & Human Services - Rockville MD
International Classification:

C07D259/00
US Classification:

514183000, 540474000, 540475000
Abstract:

The present invention provides compound of the formula (I): in which at least two of R, R, R, R, R, and Rare NOM and related compounds, substrates, compositions, and methods of using such compounds and compositions to treat biological disorders in which a polyphasic release of nitric oxide would be beneficial.

News

By Andrew Morton For The Daily Mail

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I went to a pop concert (in 1987), David Bowie, with (my friend) David Waterhouse and (Princess Margarets son) David Linley. I went in leather trousers, which I thought was the right thing to do, completely putting out of mind that I was the future Queen and future Queens dont wear leather like I was totally shocked by the attention. (David was) laughing about it, thinking it was all funny, whereas I didnt. When I went to the David Bowie concert, David Waterhouse, who I shouldnt have taken anyway, came and sat on my right. The picture ran on every front page on Monday morning.
Date: Jun 15, 2017
Source: Google