David H Weinstein

US Patent:

7888381, Feb 15, 2011

Filed:

Jun 13, 2006

Appl. No.:

11/451660

Inventors:

Jingwu Duan - Yardley PA, US
Zhonghui Lu - King of Prussia PA, US
David S. Weinstein - East Windsor NJ, US
Bin Jiang - Norristown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 231/56
A01N 43/56

US Classification:

514406, 5483601

Abstract:

Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

8304539, Nov 6, 2012

Filed:

Feb 5, 2009

Appl. No.:

12/866270

Inventors:

Jingwu Duan - Yardley PA, US
David S. Weinstein - East Windsor NJ, US
Bin Jiang - Norristown PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 491/147
C07D 413/00

US Classification:

544126, 546 83

Abstract:

Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; •A is a S- to 8-membered carbocyclic ring or a S- to 8-membered heterocyclic ring; Band Brings are pyridyl rings, wherein the Band Brings are each fused to the A ring and the Bring is optionally substituted by one to three groups which are the same or different and are independently selected from R, R, and R, and the Bring is optionally substituted by one to three groups which are the same or different and are independently selected from R, R, and RJ, J, and Jare at each occurrence the same or different and are independently -AQA-; Q is a bond, O, S, S(O), or S(O); Aand Aare the same or different and are at each occurrence independently selected from a bond, Calkylene, substituted Calkylene, Calkenylene, and substituted Calkenylene, provided that Aand Aare chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; Rto Rare as defined herein.

US Patent:

7361654, Apr 22, 2008

Filed:

Jan 12, 2006

Appl. No.:

11/330553

Inventors:

James Sheppeck - Newtown PA, US
T. G. Murali Dhar - Newtown PA, US
Lidia Doweyko - Long Valley NJ, US
John Gilmore - Yardley PA, US
David Weinstein - East Windsor NJ, US
Bingwei V. Yang - Belle Mead NJ, US
Arthur M. Doweyko - Long Valley NJ, US

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 31/5377
A61K 31/506
A61K 31/501
A61K 31/497
A61K 31/496
A61K 31/4439
A61K 31/427
A61K 31/426
A61K 31/4196
A61K 31/4168

US Classification:

5142355, 51425213, 51425205, 5142531, 51425402, 514256, 514274, 514340, 514342, 514371, 514383, 514398, 514392, 544111, 544238, 544298, 544359, 5462681, 5462684, 548190, 5483147, 5483325, 5482654, 548233, 5483044

Abstract:

The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure.

US Patent:

20220224691, Jul 14, 2022

Filed:

Nov 16, 2021

Appl. No.:

17/527957

Inventors:

- New Hope PA, US
Anton Djamoos - New Hope PA, US
David Weinstein - New Hope PA, US
Omar Beiruty - New Hope PA, US
Jeremy Zorn - New Hope PA, US

International Classification:

H04L 9/40
G06F 16/9535
H04L 67/306
H04L 65/1069

Abstract:

Nextdate provides an online dating and game experience for all participants, including live streamers, contestants, and viewers. Nextdate offers advantages over both offline and online speed dating. In respect to offline speed dating, Nextdate is better in that it provides conversational prompts to the participants (the “star” and the contestant), as well as a “Love-o-meter” and audience comments that provide additional items and context to which the participants can respond. In respect to online speed dating, Nextdate includes features that remove the friction from traditional online dating experience and encourage user participation. Nextdate may be implemented as a standalone app or as a tab or feature of another video-centric social networking app.

US Patent:

20210253554, Aug 19, 2021

Filed:

Apr 28, 2021

Appl. No.:

17/242428

Inventors:

- Princeton NJ, US
Michael G. Yang - Narberth PA, US
Zili Xiao - East Windsor NJ, US
Ling Chen - Doylestown PA, US
Ryan M. Moslin - Princeton NJ, US
John S. Tokarski - Princeton NJ, US
David S. Weinstein - San Diego CA, US
Stephen T. Wrobleski - Flemington NJ, US

International Classification:

C07D 401/14
C07D 401/12
C07D 413/14
C07D 471/04
C07D 405/14
C07F 9/6558
C07D 417/14
A61P 37/00
A61P 29/00
A61K 31/501
C07D 487/04

Abstract:

Compounds having the following formula I:or a stereoisomer or pharmaceutically-acceptable salt thereof, where R, R, R, R, and Rare as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

US Patent:

20210032220, Feb 4, 2021

Filed:

Mar 20, 2019

Appl. No.:

16/982937

Inventors:

- Princeton NJ, US
Michael G. Yang - Narberth PA, US
Chunjian C. Liu - Pennington NJ, US
Trevor C. Sherwood - West Windsor NJ, US
John L. Gilmore - Yardley PA, US
David S. Weinstein - San Diego CA, US

International Classification:

C07D 401/14
C07D 417/14
C07D 513/04
C07D 413/14

Abstract:

Compounds having the following formula (I) or a stereoisomer or pharmaceutically-acceptable salt thereof, where R, R, R, R, and Rare as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

US Patent:

20210037020, Feb 4, 2021

Filed:

Sep 25, 2019

Appl. No.:

16/582334

Inventors:

- New Hope PA, US
Anton Djamoos - New Hope PA, US
David Weinstein - New Hope PA, US
Omar Beiruty - New Hope PA, US
Jeremy Zorn - New Hope PA, US

International Classification:

H04L 29/06
G06F 16/9535
H04L 29/08

Abstract:

Nextdate provides an online dating and game experience for all participants, including live streamers, contestants, and viewers. Nextdate offers advantages over both offline and online speed dating. In respect to offline speed dating, Nextdate is better in that it provides conversational prompts to the participants (the “star” and the contestant), as well as a “Love-o-meter” and audience comments that provide additional items and context to which the participants can respond. In respect to online speed dating, Nextdate includes features that remove the friction from traditional online dating experience and encourage user participation. Nextdate may be implemented as a standalone app or as a tab or feature of another video-centric social networking app.

US Patent:

20160318870, Nov 3, 2016

Filed:

Sep 8, 2014

Appl. No.:

14/917420

Inventors:

- Princeton NJ, US
Jingwu Duan - Yardley PA, US
Hua Gong - Newtown PA, US
Bin Jiang - Bryn Mawr PA, US
Zhonghui Lu - King of Prussia PA, US
David S. Weinstein - Princeton NJ, US

Assignee:

BRISTOL-MYERS SQUIBB COMPANY - Princeton NJ

International Classification:

C07D 215/58
C07D 401/06
C07D 401/12
C07D 471/10
C07D 279/16
C07D 405/14
C07D 405/12
C07D 491/044
C07D 409/12
C07D 417/12
C07D 413/12
C07D 487/10

Abstract:

Described are RORγ modulators of the formula (I), or pharmaceutically acceptable salts thereof, wherein all substituents are defined herein. The invention includes stereoisomeric forms of the compounds of formula I, including stereoisomerically-pure, scalemic and racemic form, as well as tautomers thereof. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.