David A Weinstein

US Patent:

6887870, May 3, 2005

Filed:

Sep 25, 2000

Appl. No.:

09/669298

Inventors:

Saleem Ahmad - Wall NJ, US
Shung C. Wu - Princeton NJ, US
Steven V. O'Neil - Newtown PA, US
Khehyong Ngu - Pennington NJ, US
Karnail S. Atwal - Newtown PA, US
David S. Weinstein - East Windsor NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K031/4427
C07D401/04

US Classification:

5142358, 514241, 514242, 514250, 51425309, 5142531, 514256, 51425941, 5142601, 514300, 514320, 514321, 514322, 514323, 514326, 544122, 544182, 544212, 544278, 544281, 544322, 544328, 544331, 544349, 544360, 546121, 546198, 546199, 546201, 546208, 546209, 546210, 546212, 546214

Abstract:

Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C—Rwherein Ris H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl gorup, R, R, Rand Rare as defined herein, and where X is N. Ris preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.

US Patent:

7253283, Aug 7, 2007

Filed:

Jan 13, 2005

Appl. No.:

11/035176

Inventors:

David S. Weinstein - East Windsor NJ, US
John L. Gilmore - Yardley PA, US
James Sheppeck - Newtown PA, US
Bingwei Vera Yang - Belle Mead NJ, US
Soong-Hoon Kim - Titusville NJ, US
Wayne Vaccaro - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Pricneton NJ

International Classification:

C07D 417/02
C07D 413/02
A61K 31/473

US Classification:

546 99, 546 97, 514295, 514256

Abstract:

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).

US Patent:

7317032, Jan 8, 2008

Filed:

Sep 1, 2004

Appl. No.:

10/932594

Inventors:

David S. Weinstein - East Windsor NJ, US
Khehyong Ngu - Pennington NJ, US
Jeffrey A. Robl - Newtown PA, US

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

A61K 31/415
C07D 233/00

US Classification:

514385, 5483001

Abstract:

The present invention provides imidazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

US Patent:

7326705, Feb 5, 2008

Filed:

Jan 31, 2005

Appl. No.:

11/046993

Inventors:

Saleem Ahmad - Wall NJ, US
Shung C. Wu - Princeton NJ, US
Steven V. O'Neil - Newtown PA, US
Khehyong Ngu - Pennington NJ, US
Karnail S. Atwal - Newtown PA, US
David S. Weinstein - East Windsor NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/535
A61K 31/505
A61K 31/41
A01N 43/40
A01N 43/50
A01K 31/44
C07D 239/02
C07D 471/02
C07D 491/02
C07D 498/02
C07D 513/02
C07D 515/02
C07D 401/00

US Classification:

5142358, 514275, 514326, 514300, 514399, 514383, 544329, 546118, 546210, 546211, 5483265

Abstract:

Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure.

US Patent:

7351727, Apr 1, 2008

Filed:

Sep 1, 2004

Appl. No.:

10/932457

Inventors:

David S. Weinstein - East Windsor NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/425
C07D 327/04

US Classification:

514365, 549 30

Abstract:

The present invention provides oxazolyl and thiazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

US Patent:

7429611, Sep 30, 2008

Filed:

Sep 21, 2005

Appl. No.:

11/232063

Inventors:

David S. Weinstein - East Windsor NJ, US
Charles M. Langevine - Brooklyn NY, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/405
C07D 403/02

US Classification:

514414, 514419, 548465, 548492

Abstract:

The present invention provides indole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

US Patent:

7534804, May 19, 2009

Filed:

Aug 24, 2006

Appl. No.:

11/509373

Inventors:

David S. Weinstein - East Windsor NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/423
C07D 263/54

US Classification:

514375, 548215, 548217, 514374

Abstract:

The present application provides benzoxazole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

US Patent:

7544808, Jun 9, 2009

Filed:

Jul 5, 2007

Appl. No.:

11/773506

Inventors:

David S. Weinstein - East Windsor NJ, US
John L. Gilmore - Yardley PA, US
James Sheppeck - Newtown PA, US
Bingwei Vera Yang - Belle Mead NJ, US
Soong-Hoon Kim - Titusville NJ, US
Wayne Vaccaro - Yardley PA, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 277/20
A61K 31/425

US Classification:

548185, 548233, 5482654, 5483325, 514371, 514377, 514383, 514398

Abstract:

Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I).