Karlyne Reilly - Potomac MD, US Thomas Turbyville - Frederick MD, US John A. Beutler - Union Bridge MD, US David Wiemer - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES - Bethesda MD
Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.