David E Wiemer

US Patent:

20120095089, Apr 19, 2012

Filed:

Apr 30, 2010

Appl. No.:

13/266841

Inventors:

Karlyne Reilly - Potomac MD, US
Thomas Turbyville - Frederick MD, US
John A. Beutler - Union Bridge MD, US
David Wiemer - Iowa City IA, US

Assignee:

UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA
THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES - Bethesda MD

International Classification:

A61K 31/352
A61P 25/02
A61P 25/00
A61P 9/10
A61P 7/00
A61P 35/00
C07D 311/82

US Classification:

514454, 549388

Abstract:

Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.