David M Wolf

US Patent:

7247018, Jul 24, 2007

Filed:

May 18, 2004

Appl. No.:

10/848929

Inventors:

George Kantor - Denver CO, US
Paul Ritter Smith - Denver CO, US
Michael Dean Stevens - Littleton CO, US
Daphne Upchurch - Lakewood CO, US
David R. Wolf - Lakewood CO, US
Rosilio Ronald Perez - Vista CA, US

Assignee:

RMO, Inc. - Denver CO

International Classification:

A61C 3/00

US Classification:

433 9

Abstract:

An improved edgewise orthodontic bracket is disclosed. In one embodiment, a bracket comprises a single pair of opposing T-shaped tie wings which define an archwire slot therebetween. Notches are provided on each of the mesial and distal sides of the center leg of each T-shaped tie wing for selectively receiving a ligating device. The notches are defined in the gingival/occlusal edges of the tie wings and comprise sloped portions that extend labially towards the archwire slot. Convex sidewall portions and convex floor portions are provided in the archwire slot adjacent to the notches. The body of the bracket is interconnected to a base that includes a continuous series of characters that serve as texturing to facilitate bonding of the bracket with a tooth. A discontinuous perimeter rail may be used at the edge of the base. A method for forming a bracket is also provided.

US Patent:

20040072757, Apr 15, 2004

Filed:

Nov 13, 2003

Appl. No.:

10/712332

Inventors:

David Wolf - Davis CA, US
Uma Sinha - San Francisco CA, US

Assignee:

COR Therapeutics, Inc.

International Classification:

A61K038/37

US Classification:

514/012000

Abstract:

Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition, modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilic conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.

US Patent:

20070264606, Nov 15, 2007

Filed:

Apr 26, 2007

Appl. No.:

11/740812

Inventors:

Chris Muha - Centennial CO, US
David Wolf - Lakewood CO, US
Daphne Upchurch - Lakewood CO, US
Leon Laub - Fort Collins CO, US
Robert Rudman - Denver CO, US

Assignee:

RMO, INC. - Denver CO

International Classification:

A61C 3/00

US Classification:

433017000

Abstract:

A convertible orthodontic bracket is disclosed, wherein an archwire slot therein has a removable slot covering, thereby allowing the bracket to serve as a buccal tube during a first stage of treatment and an edgewise bracket during a subsequent phase of treatment. The slot covering is removable by detaching the slot covering from the bracket body along one or more predetermined extents of weakness, wherein each such extent of weakness includes perforations or voids providing a passage between an exterior of the bracket and an interior of the first archwire slot.

US Patent:

20080138759, Jun 12, 2008

Filed:

Sep 19, 2007

Appl. No.:

11/858076

Inventors:

Neal D. Kravitz - Fairfax Station VA, US
David Wolf - Lakewood CO, US
Leon W. Laub - Fort Collins CO, US

International Classification:

A61C 7/00

US Classification:

433 21, 433 18, 433 24

Abstract:

An orthodontic appliance for orthodontic treatment includes first and second eyelets connected to coil spring at each end of the coil spring, thereby forming a double eyelet and spring unit. In one embodiment, a connector for detachably attaching a spring to an orthodontic appliance includes a means for engaging an appliance. In one embodiment the connector is an eyelet having an aperture in its central region for allowing the spring to be detachably attached to the orthodontic appliance. The aperture may have a variety of shapes. Alternatively, the connector may comprise a hook or equivalent structure for facilitating the spring to be attached to the orthodontic appliance.

US Patent:

20080160474, Jul 3, 2008

Filed:

Apr 2, 2007

Appl. No.:

11/695555

Inventors:

David Wolf - Lakewood CO, US
Tony Zakhem - Highlands Ranch CO, US
Leon Laub - Fort Collins CO, US
Michael Stevens - Littleton CO, US
George Kantor - Denver CO, US

Assignee:

RMO, INC. - Denver CO

International Classification:

A61C 7/14
A61C 7/28

US Classification:

433 10

Abstract:

A triple wing orthodontic bracket, bracket cover, and method of use is disclosed. The bracket has a slot liner for reducing friction between an archwire and the bracket, wherein the liner is flared at its ends. The bracket cover has: a rod-shaped hinge for rotating in recesses between a bracket base, and bracket wings on one of a gingival and occlusal bracket side, a slot cover, and a cross member for rotating the slot cover between covering a bracket archwire slot, and uncovering the slot, wherein the rotation pivots the hinge in the recesses. The hinge and recesses frictionally engage one another, wherein in a first position, the hinge attaches and detaches from the bracket, and after pivoting the hinge to another position in the recesses, the hinge is secured therein. Interaction between the hinge and the recesses may cause the slot cover to move to cover the slot.

US Patent:

56354819, Jun 3, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/467339

Inventors:

David Wolf - Palo Alto CA

Assignee:

COR Therapeutics, Inc. - South San Francisco CA

International Classification:

A61K 3836
A61K 3516
C07K 1447
C07K 14745

US Classification:

514 12

Abstract:

Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.

US Patent:

59900792, Nov 23, 1999

Filed:

Jan 30, 1998

Appl. No.:

9/016400

Inventors:

David L. Wolf - Palo Alto CA
Uma Sinha - San Francisco CA

Assignee:

COR Therapeutics Inc. - South San Francisco CA

International Classification:

A61K 3836
A61K 3516
A61F 1300
C07K 14435

US Classification:

514 2

Abstract:

Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition, modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilia conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.

US Patent:

54967244, Mar 5, 1996

Filed:

May 24, 1993

Appl. No.:

8/067139

Inventors:

Robert M. Scarborough - Belmont CA
David L. Wolf - Palo Alto CA
Israel F. Charo - Lafayette CA

Assignee:

COR Therapeutics, Inc. - South San Francisco CA

International Classification:

C12N 121
C12N 1571
C12N 119
C12N 1512

US Classification:

4352523

Abstract:

An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R. sup. 1. sub. 2 N(CH. sub. 2). sub. 4 CHNHCO-- wherein each R. sup. 1 is independently H, alkyl(1-6C) or at most one R. sup. 1 is R. sup. 2 --C. dbd. NR. sup. 3 wherein R. sup. 2 is H, alkyl(1-6C) or is NR. sup. 4. sub.